PMID- 19460559
OWN - NLM
STAT- MEDLINE
DCOM- 20141210
LR  - 20090522
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 41
IP  - 4
DP  - 2009 May
TI  - Long-term mechanical support with the HeartMate II LVAS.
PG  - 1357-9
LID - 10.1016/j.transproceed.2009.03.020 [doi]
AB  - BACKGROUND: The use of left ventricular assist devices (LVAD) is an accepted 
      therapy for patients with refractory heart failure. The HeartMate II is a small 
      (350 g), implantable, axial-flow pump (nonpulsatile flow), which is designed to 
      support the left ventricle for extended periods of time. Here we have reported 
      our initial single-center clinical experience with this device as a bridge to 
      heart transplantation. MATERIALS AND METHODS: Between March 2002 and December 
      2008, 18 transplantable adult patients were supported on long-term HeartMate II 
      LVAS at our institution. The cohort included 15 men with an overall mean age of 
      52 +/- 8.4 years (range, 31-64 years). Primary indications for implantation were 
      ischemic cardiomyopathy (CMP; n = 13) and idiopathic CMP (n = 5). All heart 
      failure patients were New York Heart Association (NYHA) functional class IV. None 
      of them had undergone prior open heart surgery. Implantation was performed via 
      cannulation of the left ventricular apex and ascending aorta, and in each case 
      was an elective procedure. RESULTS: Mean support time was 217 +/- 212.3 days 
      (range, 1-665 days). Early (30-day) mortality was 27.7% (n = 5) due to multiple 
      organ failure and sepsis as main causes of death. Bleeding requiring reoperation 
      occurred in 6 cases (33.3%). Cerebral hemorrhage occurred in 1 case. There were 2 
      driveline infections and no device failure. Twelve subjects (66.6%) were 
      successfully discharged home. Overall, 9 patients (50%) underwent transplantation 
      and 3 are awaiting a suitable organ (2 were discharged home and 1 is in 
      hospital). At latest follow-up, the survival rate after heart transplantation was 
      66.6% (n = 6). CONCLUSIONS: Long-term HeartMate II LVAS can successfully bridge 
      patients to heart transplantation. Good mid- and long-term results may support 
      the use of this device even for a permanent solution in nontransplantable 
      subjects.
FAU - Loforte, A
AU  - Loforte A
AD  - Department of Cardiac Surgery and Heart Transplantation, San Camillo Hospital, 
      Rome, Italy. antonioloforte@yahoo.it
FAU - Montalto, A
AU  - Montalto A
FAU - Ranocchi, F
AU  - Ranocchi F
FAU - Casali, G
AU  - Casali G
FAU - Luzi, G
AU  - Luzi G
FAU - Della Monica, P L
AU  - Della Monica PL
FAU - Sbaraglia, F
AU  - Sbaraglia F
FAU - Polizzi, V
AU  - Polizzi V
FAU - Distefano, G
AU  - Distefano G
FAU - Musumeci, F
AU  - Musumeci F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Female
MH  - Heart Transplantation
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2009/05/23 09:00
MHDA- 2014/12/15 06:00
CRDT- 2009/05/23 09:00
PHST- 2009/05/23 09:00 [entrez]
PHST- 2009/05/23 09:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0041-1345(09)00407-2 [pii]
AID - 10.1016/j.transproceed.2009.03.020 [doi]
PST - ppublish
SO  - Transplant Proc. 2009 May;41(4):1357-9. doi: 10.1016/j.transproceed.2009.03.020.