PMID- 19462275
OWN - NLM
STAT- MEDLINE
DCOM- 20090824
LR  - 20090522
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 31
IP  - 4
DP  - 2009
TI  - Contribution of renal function impairment to unexplained troponin T elevations in 
      congestive heart failure.
PG  - 272-7
LID - 10.1080/08860220902780119 [doi]
AB  - BACKGROUND: Patients with severe congestive heart failure (CHF) often have 
      unexplained elevations in serum concentrations of troponin T (TnT), and it is 
      proposed that this is due to cardiac TnT release because of underlying cardiac 
      disease. We investigated whether impaired renal function is an additional 
      underlying phenomenon contributing to increased TnT levels in patients with CHF. 
      METHODS: Sixty-two patients with nonischemic CHF, New York Heart Association 
      (NYHA) class III-IV, with normal coronary angiogram and normal serum creatinine 
      were included in the study. Baseline glomerular filtration rate (GFR) was 
      calculated using the Cockcroft Gault equation. RESULTS: Although mean creatinine 
      level was normal (0.92 +/- 0.17 mg/dL), mean GFR was low (56 +/- 16 mL/min) in 
      the cohort. Elevated (>or=0.02 microg/L) TnT was measured in 33 patients (53%). 
      Compared with patients with normal (<0.02 microg/L) TnT levels, patients with 
      elevated TnT had significantly higher NYHA class (p = 0.02), longer duration of 
      disease (p = 0.02), lower GFR (p = 0.0001), and lower LVEF (p = 0.0001). There 
      were significant associations between TnT levels and duration of disease (r = 
      0.29, p = 0.01), creatinine (r = 0.30, p = 0.01), GFR (r = -0.55, p < 0.0001), 
      and LVEF (r = -0.39, p = 0.001). Independence of these associations was evaluated 
      in multiple linear regression analysis, and serum TnT was independently and 
      negatively associated only with GFR (p = 0.005). CONCLUSIONS: Renal function 
      (GFR) correlated significantly and more strongly than cardiac function (LVEF) 
      with the serum TnT levels in patients with CHF. This supports our hypothesis that 
      impaired renal function causes the accumulation of troponin and is very likely 
      the cause of unexplained elevations of serum TnT in patients severe CHF.
FAU - Aksoy, Nur
AU  - Aksoy N
AD  - Gaziantep University, School of Medicine, Department of Biochemistry, Gaziantep, 
      Turkey. naksoy@gantep.edu.tr
FAU - Ozer, Orhan
AU  - Ozer O
FAU - Sari, Ibrahim
AU  - Sari I
FAU - Sucu, Murat
AU  - Sucu M
FAU - Aksoy, Mehmet
AU  - Aksoy M
FAU - Geyikli, Iclal
AU  - Geyikli I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Troponin T)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Heart Failure/*blood/*physiopathology
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Troponin T/*blood
EDAT- 2009/05/23 09:00
MHDA- 2009/08/25 09:00
CRDT- 2009/05/23 09:00
PHST- 2009/05/23 09:00 [entrez]
PHST- 2009/05/23 09:00 [pubmed]
PHST- 2009/08/25 09:00 [medline]
AID - 911583683 [pii]
AID - 10.1080/08860220902780119 [doi]
PST - ppublish
SO  - Ren Fail. 2009;31(4):272-7. doi: 10.1080/08860220902780119.