PMID- 19462556
OWN - NLM
STAT- MEDLINE
DCOM- 20090609
LR  - 20151119
IS  - 0120-4157 (Print)
IS  - 0120-4157 (Linking)
VI  - 28
IP  - 4
DP  - 2008 Dec
TI  - [Autoimmune syndrome in the tropical spastic paraparesis/myelopathy associated 
      with human T-lymphotropic virus infections].
PG  - 510-22
AB  - INTRODUCTION: Previous reports have given evidence that in tropical spastic 
      paraparesis (TSP)/human T-lymphotrophic virus (HTLV-I)-associated myelopathy 
      (HAM), an autoimmune process occurs as part of its pathogenesis. OBJECTIVE: The 
      roles of autoimmunity and the molecular mimicry was evaluated in TSP/HAM 
      patients. MATERIALS AND METHODS: Plasma samples were characterized from patients 
      in the Pacific coastal region of Colombia. Thirty-seven were identified as 
      TSP/HAM, 10 were diagnosed with adult T-cell leukemia virus, 22 were asymptomatic 
      carriers but seropositive for HTLV-I and 20 were seronegative and served as 
      negative controls. Plasmatic levels of the following were determined: antinuclear 
      antibody (ANA) levels, anticardiolipine-2 (ACL-2), interferon- (IFN-gamma) and 
      interleukin-4 (IL-4). Using Western blot, the crossreactivity of the seropositive 
      and seronegative samples was evaluated against proteins extracted from several 
      central nervous system components of non infected Wistar rats. The HTLV-I 
      seropositive plasmas were crossreacted with a monoclonal tax (LT4 anti-taxp40) 
      from spinal cord neurons of non infected Wistar rats. RESULTS: Of the TSP/HAM 
      patients, 70.2% were reactive against ANA and 83.8% against ACL-2, in contrast 
      with those ATL and asymptomatic seropositives subjects that were not reactive 
      (P<0.001). Moreover, 70.3% had detectable levels of IFN and 43.2% had detectable 
      IL-4. LT4 anti-taxp40 and plasma of TSP/HAM exhibited cross reactivity with a MW 
      33-35 kDa protein from the rat spinal cord nuclei. CONCLUSION: Support was 
      provided for the existence of an autoimmune syndrome mediated by molecular 
      mimicry; the syndrome was responsible for some of the axonal degeneration 
      observed in TSP/HAM patients.
FAU - Dominguez, Martha C
AU  - Dominguez MC
AD  - Laboratorio de Biologia Molecular y Patogenesis, Departamento de Ciencias 
      Fisiologicas, Escuela de Ciencias Basicas, Facultad de Salud, Universidad del 
      Valle, Cali, Colombia.
FAU - Torres, Miyerlandi
AU  - Torres M
FAU - Tamayo, Oscar
AU  - Tamayo O
FAU - Criollo, William
AU  - Criollo W
FAU - Quintana, Milton
AU  - Quintana M
FAU - Sanchez, Adalberto
AU  - Sanchez A
FAU - Garcia, Felipe
AU  - Garcia F
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Sindrome autoinmune en la paraparesia tropical espastica/mielopatia asociada a la 
      infeccion por el virus linfotropico humano tipo I de la costa pacifica 
      colombiana.
PL  - Colombia
TA  - Biomedica
JT  - Biomedica : revista del Instituto Nacional de Salud
JID - 8205605
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Autoantibodies/blood/immunology
MH  - *Autoimmune Diseases/blood/immunology/pathology
MH  - Biomarkers/metabolism
MH  - *HTLV-I Infections/blood/immunology/pathology
MH  - Human T-lymphotropic virus 1/immunology
MH  - Humans
MH  - Molecular Mimicry
MH  - *Paraparesis, Tropical Spastic/blood/immunology/pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Spinal Cord/pathology
EDAT- 2009/05/26 09:00
MHDA- 2009/06/10 09:00
CRDT- 2009/05/26 09:00
PHST- 2009/05/26 09:00 [entrez]
PHST- 2009/05/26 09:00 [pubmed]
PHST- 2009/06/10 09:00 [medline]
AID - S0120-41572008000400005 [pii]
PST - ppublish
SO  - Biomedica. 2008 Dec;28(4):510-22.