PMID- 19463115
OWN - NLM
STAT- MEDLINE
DCOM- 20090630
LR  - 20170310
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 49
IP  - 4
DP  - 2009
TI  - [The study of peculiarities of immunotropic action of statins in chronic heart 
      failure of various etiology].
PG  - 29-36
AB  - AIM: To study features of statin therapy in patients with heart failure (HF) of 
      different etiology on immune system. MATERIAL AND METHODS: The basic markers of 
      immune activation in 43 patients with chronic heart disease (CHD) and HF in New 
      York Heart Association (NYHA) class I to IV were studied. Mine age was 48 +/- 8 
      years (from 33 to 64 years). 43 patients with dilated cardiomyopathy (DCM) and HF 
      were also observed. Mine age was 43 +/- 10 years (from 22 to 61 years). 
      Parameters of systolic and diastolic left ventricle (LV) function were measured. 
      Also non invasive methods for evaluation of endothelial function were used. 
      Concentrations of hsCRP, IgG, IgA, IgM were measured using commercially available 
      kits. IL 6, IL 8, sIL 2R, IL 18, IL 10, IFN Y, endothelin levels were measured 
      using enzyme linked immunosorbent assay method. RESULTS: Statin therapy has 
      immunomodulation effect in patients with heart failure any etiology. This effect 
      depends on etiology of HF. In CHD patients the decreasing of IFN Y, IL 8, sIL 2R, 
      hsCRP and increasing of IL 18, IL 6 levels were observed. In DCM patients the 
      decreasing of IL 8, IL 18, sIL 2R and increasing of IL 10 were observed. There 
      was significant clinical improving in patients with DCM and HF after statin 
      therapy. But there were no changes of endothelial function in patients with CHD 
      and DCM. There were no changes of LV function in patients with CHD. So statin 
      therapy may reduce level of proinflammatory mediators but not fully control 
      inflammation process in patients with HF of different etiology.
FAU - Zykov, K A
AU  - Zykov KA
FAU - Tatenkulova, S N
AU  - Tatenkulova SN
FAU - Mareev, V Iu
AU  - Mareev VIu
FAU - Masenko, B P
AU  - Masenko BP
FAU - Balakhonova, T V
AU  - Balakhonova TV
FAU - Tripoten', M I
AU  - Tripoten' MI
FAU - Kaznacheeva, E I
AU  - Kaznacheeva EI
FAU - Beliavskii, E A
AU  - Beliavskii EA
FAU - Tkachev, G A
AU  - Tkachev GA
FAU - Belenkov, Iu N
AU  - Belenkov IuN
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
RN  - 0 (Cytokines)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/blood/*complications/physiopathology
MH  - Cytokines/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heart Failure/drug therapy/etiology/*immunology
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Immunity/*drug effects
MH  - Immunoglobulins/blood
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
MH  - Ventricular Function, Left/physiology
MH  - Young Adult
EDAT- 2009/05/26 09:00
MHDA- 2009/07/01 09:00
CRDT- 2009/05/26 09:00
PHST- 2009/05/26 09:00 [entrez]
PHST- 2009/05/26 09:00 [pubmed]
PHST- 2009/07/01 09:00 [medline]
PST - ppublish
SO  - Kardiologiia. 2009;49(4):29-36.