PMID- 19464074
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20191210
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 32
IP  - 5
DP  - 2011 May
TI  - Chronic nicotine restores normal Abeta levels and prevents short-term memory and 
      E-LTP impairment in Abeta rat model of Alzheimer's disease.
PG  - 834-44
LID - 10.1016/j.neurobiolaging.2009.04.015 [doi]
AB  - Alzheimer's disease (AD) is a devastating neurodegenerative disorder 
      characterized by increased deposition of beta-amyloid (Abeta) peptides and 
      progressive cholinergic dysfunction in regions of the brain involved in learning 
      and memory processing. In AD, progressive accumulation of Abeta peptide impairs 
      nicotinic acetylcholine receptor (nAChR) function by an unknown mechanism 
      believed to involve alpha(7)- and alpha(4)beta(2)-nAChR blockade. The three approaches of 
      the current study evaluated the effects of chronic nicotine treatment in the 
      prevention of Abeta-induced impairment of learning and short-term memory. Rat AD 
      model was induced by 14-day i.c.v. osmotic pump infusion of a 1:1 mixture of 300 
      pmol/day Abeta(1-40)/Abeta(1-42) or Abeta(40-1) (inactive peptide, control). The effect of 
      nicotine (2 mg/(kg day)) on Abeta-induced spatial learning and memory impairments 
      was assessed by evaluation of performance in the radial arm water maze (RAWM), in 
      vivo electrophysiological recordings of early-phase long-term potentiation 
      (E-LTP) in urethane-anesthetized rats, and immunoblot analysis to determine 
      changes in the levels of beta-site amyloid precursor protein (APP)-cleaving 
      enzyme (BACE), Abeta and memory-related proteins. The results indicate that 6 weeks 
      of nicotine treatment reduced the levels of Abeta(1-40) and BACE1 peptides in 
      hippocampal area CA1 and prevented Abeta-induced impairment of learning and 
      short-term memory. Chronic nicotine also prevented the Abeta-induced inhibition of 
      basal synaptic transmission and LTP in hippocampal area CA1. Furthermore, chronic 
      nicotine treatment prevented the Abeta-induced reduction of alpha(7)- and alpha(4)-nAChR. 
      These effects of nicotine may be due, at least in part, to upregulation of brain 
      derived neurotropic factor (BDNF).
CI  - Copyright (c) 2009 Elsevier Inc. All rights reserved.
FAU - Srivareerat, Marisa
AU  - Srivareerat M
AD  - Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, 
      University of Houston, Houston, TX 77204, United States.
FAU - Tran, Trinh T
AU  - Tran TT
FAU - Salim, Samina
AU  - Salim S
FAU - Aleisa, Abdulaziz M
AU  - Aleisa AM
FAU - Alkadhi, Karim A
AU  - Alkadhi KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090522
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ganglionic Stimulants)
RN  - 0 (Receptors, Nicotinic)
RN  - 6M3C89ZY6R (Nicotine)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - EC 3.4.23.46 (Bace1 protein, rat)
SB  - IM
MH  - Alzheimer Disease/*drug therapy
MH  - Amyloid Precursor Protein Secretases/metabolism
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Aspartic Acid Endopeptidases/metabolism
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - CA1 Region, Hippocampal/drug effects
MH  - Disease Models, Animal
MH  - Ganglionic Stimulants/*therapeutic use
MH  - Learning/drug effects
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*drug therapy
MH  - Memory, Short-Term/*drug effects
MH  - Nicotine/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Nicotinic/drug effects
MH  - Synaptic Transmission/drug effects
MH  - Up-Regulation
EDAT- 2009/05/26 09:00
MHDA- 2011/08/19 06:00
CRDT- 2009/05/26 09:00
PHST- 2008/11/14 00:00 [received]
PHST- 2009/04/15 00:00 [revised]
PHST- 2009/04/19 00:00 [accepted]
PHST- 2009/05/26 09:00 [entrez]
PHST- 2009/05/26 09:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0197-4580(09)00142-0 [pii]
AID - 10.1016/j.neurobiolaging.2009.04.015 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2011 May;32(5):834-44. doi: 
      10.1016/j.neurobiolaging.2009.04.015. Epub 2009 May 22.