PMID- 19465137
OWN - NLM
STAT- MEDLINE
DCOM- 20091009
LR  - 20220309
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 47
IP  - 3
DP  - 2009 Sep
TI  - Brain mediators of cardiovascular responses to social threat: part I: Reciprocal 
      dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate 
      reactivity.
PG  - 821-35
LID - 10.1016/j.neuroimage.2009.05.043 [doi]
AB  - Social threat is a key component of mental "stress" and a potent generator of 
      negative emotions and physiological responses in the body. How the human brain 
      processes social context and drives peripheral physiology, however, is relatively 
      poorly understood. Human neuroimaging and animal studies implicate the dorsal 
      medial prefrontal cortex (MPFC), though this heterogeneous region is likely to 
      contain multiple sub-regions with diverse relationships with physiological 
      reactivity and regulation. We used fMRI combined with a novel multi-level path 
      analysis approach to identify brain mediators of the effects of a public speech 
      preparation task (social evaluative threat, SET) on heart rate (HR). This model 
      provides tests of functional pathways linking experimentally manipulated threat, 
      regional fMRI activity, and physiological output, both across time (within 
      person) and across individuals (between persons). It thus integrates time series 
      connectivity and individual difference analyses in the same path model. The 
      results provide evidence for two dissociable, inversely coupled sub-regions of 
      MPFC that independently mediated HR responses. SET caused activity increases in a 
      more dorsal pregenual cingulate region, whose activity was coupled with HR 
      increases. Conversely, SET caused activity decreases in a right 
      ventromedial/medial orbital region, which were coupled with HR increases. 
      Individual differences in coupling strength in each pathway independently 
      predicted individual differences in HR reactivity. These results underscore both 
      the importance and heterogeneity of MPFC in generating physiological responses to 
      threat.
FAU - Wager, Tor D
AU  - Wager TD
AD  - Department of Psychology, Columbia University, 1190 Amsterdam Ave., New York, NY 
      10027, USA. tor@psych.columbia.edu
FAU - Waugh, Christian E
AU  - Waugh CE
FAU - Lindquist, Martin
AU  - Lindquist M
FAU - Noll, Doug C
AU  - Noll DC
FAU - Fredrickson, Barbara L
AU  - Fredrickson BL
FAU - Taylor, Stephan F
AU  - Taylor SF
LA  - eng
GR  - R01 MH076136-02/MH/NIMH NIH HHS/United States
GR  - MH59615/MH/NIMH NIH HHS/United States
GR  - MH076136/MH/NIMH NIH HHS/United States
GR  - R01 MH076136-01A1/MH/NIMH NIH HHS/United States
GR  - R01 MH076136-03/MH/NIMH NIH HHS/United States
GR  - R01 MH059615/MH/NIMH NIH HHS/United States
GR  - R01 MH076136/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090522
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping/*methods
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Models, Neurological
MH  - Prefrontal Cortex/*physiology
MH  - Speech/physiology
MH  - Stress, Psychological/*physiopathology
PMC - PMC3275821
MID - NIHMS162254
EDAT- 2009/05/26 09:00
MHDA- 2009/10/10 06:00
PMCR- 2012/02/09
CRDT- 2009/05/26 09:00
PHST- 2009/02/10 00:00 [received]
PHST- 2009/05/11 00:00 [revised]
PHST- 2009/05/12 00:00 [accepted]
PHST- 2009/05/26 09:00 [entrez]
PHST- 2009/05/26 09:00 [pubmed]
PHST- 2009/10/10 06:00 [medline]
PHST- 2012/02/09 00:00 [pmc-release]
AID - S1053-8119(09)00555-2 [pii]
AID - 10.1016/j.neuroimage.2009.05.043 [doi]
PST - ppublish
SO  - Neuroimage. 2009 Sep;47(3):821-35. doi: 10.1016/j.neuroimage.2009.05.043. Epub 
      2009 May 22.