PMID- 19465453 OWN - NLM STAT- MEDLINE DCOM- 20090910 LR - 20191210 IS - 1352-4585 (Print) IS - 1352-4585 (Linking) VI - 15 IP - 7 DP - 2009 Jul TI - Retinal nerve fiber thickness in inflammatory demyelinating diseases of childhood onset. PG - 802-10 LID - 10.1177/1352458509104586 [doi] AB - PURPOSE: To evaluate retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography (OCT) in children with acquired demyelinating diseases. METHODS: This is a cross-sectional study of patients seen between 2006-2008 at the Pediatric MS Center of the Jacobs Neurological Institute. Consensus definitions for pediatric demyelinating disease were followed. All children received OCT testing and assessment of visual acuity (VA) using Snellen and low contrast letter acuity (LCLA) charts. RESULTS: Thirty-eight children diagnosed with acquired demyelinating disease, 15 healthy controls, and five children with other neurological disorders (OND) were included. Average RNFLT in healthy controls was 107 +/- 12 microm(n = 30) versus 108 +/- 5 microm (n = 10) in OND controls. In children with multiple sclerosis, average RNFLT +/- SD was 99 +/- 14 microm in unaffected (n = 24) versus 83 +/- 12 micromin eyes affected by optic neuritis ("affected eyes") (n = 10). Average RNFLT in children with acute disseminated encephalomyelitis and transverse myelitis was 102 +/- 15 microm in unaffected (n = 18) versus 67 +/- 17 microm in affected eyes (n = 6). In children with optic neuritis (ON), average RNFLT +/- SD was 97 +/- 13 microm in unaffected (n = 5) versus 89 +/- 12 microm in affected eyes (n = 9). Differences between children with demyelinating disease and controls and between ON and nonON eyes were statistically significant (P < 0.001). Bivariate correlations of RNFLT with LCLA (P = 0.002) and VA (P < 0.001) were significant. CONCLUSIONS: OCT may be a valuable tool for the assessment and monitoring of anterior optic pathway dysfunction in children with demyelinating diseases. FAU - Yeh, E A AU - Yeh EA AD - Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA. FAU - Weinstock-Guttman, B AU - Weinstock-Guttman B FAU - Lincoff, N AU - Lincoff N FAU - Reynolds, J AU - Reynolds J FAU - Weinstock, A AU - Weinstock A FAU - Madurai, N AU - Madurai N FAU - Agarwal, N AU - Agarwal N FAU - Buch, P AU - Buch P FAU - Karpinski, M AU - Karpinski M FAU - Ramanathan, M AU - Ramanathan M LA - eng GR - RG3743/RG/CSR NIH HHS/United States PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. DEP - 20090522 PL - England TA - Mult Scler JT - Multiple sclerosis (Houndmills, Basingstoke, England) JID - 9509185 SB - IM MH - Adolescent MH - Age of Onset MH - Case-Control Studies MH - Child MH - Cross-Sectional Studies MH - Demyelinating Diseases/epidemiology/*pathology/physiopathology MH - Encephalomyelitis, Acute Disseminated/pathology/physiopathology MH - Feasibility Studies MH - Female MH - Humans MH - Male MH - Multiple Sclerosis/pathology/physiopathology MH - Myelitis, Transverse/pathology/physiopathology MH - Optic Neuritis/epidemiology/*pathology/physiopathology MH - Predictive Value of Tests MH - Prospective Studies MH - Retinal Neurons/*pathology MH - *Tomography, Optical Coherence MH - *Visual Acuity EDAT- 2009/05/26 09:00 MHDA- 2009/09/11 06:00 CRDT- 2009/05/26 09:00 PHST- 2009/05/26 09:00 [entrez] PHST- 2009/05/26 09:00 [pubmed] PHST- 2009/09/11 06:00 [medline] AID - 1352458509104586 [pii] AID - 10.1177/1352458509104586 [doi] PST - ppublish SO - Mult Scler. 2009 Jul;15(7):802-10. doi: 10.1177/1352458509104586. Epub 2009 May 22.