PMID- 19465908
OWN - NLM
STAT- MEDLINE
DCOM- 20090918
LR  - 20220330
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Linking)
VI  - 10
IP  - 7
DP  - 2009 Jul
TI  - Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and 
      presentation of peptide-MHC class II complexes to CD4+ T cells.
PG  - 706-12
LID - 10.1038/ni.1737 [doi]
AB  - Basophils express major histocompatibility complex class II, CD80 and CD86 and 
      produce interleukin 4 (IL-4) in various conditions. Here we show that when 
      incubated with IL-3 and antigen or complexes of antigen and immunoglobulin E 
      (IgE), basophils internalized, processed and presented antigen as complexes of 
      peptide and major histocompatibility complex class II and produced IL-4. 
      Intravenous administration of ovalbumin-pulsed basophils into naive mice 
      'preferentially' induced the development of naive ovalbumin-specific CD4+ T cells 
      into T helper type 2 (T(H)2) cells. Mice immunized in this way, when challenged 
      by intravenous administration of ovalbumin, promptly produced ovalbumin-specific 
      IgG1 and IgE. Finally, intravenous administration of IgE complexes rapidly 
      induced T(H)2 cells only in the presence of endogenous basophils, which suggests 
      that basophils are potent antigen-presenting cells that 'preferentially' augment 
      T(H)2-IgE responses by capturing IgE complex.
FAU - Yoshimoto, Tomohiro
AU  - Yoshimoto T
AD  - Department of Immunology and Medical Zoology, Hyogo College of Medicine, 
      Nishinomiya, Hyogo, Japan.
FAU - Yasuda, Koubun
AU  - Yasuda K
FAU - Tanaka, Hidehisa
AU  - Tanaka H
FAU - Nakahira, Masakiyo
AU  - Nakahira M
FAU - Imai, Yasutomo
AU  - Imai Y
FAU - Fujimori, Yoshihiro
AU  - Fujimori Y
FAU - Nakanishi, Kenji
AU  - Nakanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090524
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Peptides)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Adoptive Transfer
MH  - Animals
MH  - Antigen-Presenting Cells/cytology/*immunology/metabolism
MH  - Basophils/*immunology/metabolism/transplantation
MH  - CD4-Positive T-Lymphocytes/cytology/*immunology/metabolism
MH  - Flow Cytometry
MH  - Histocompatibility Antigens Class II/chemistry/*immunology
MH  - Immunoglobulin E/*immunology
MH  - Interleukin-4/genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Knockout
MH  - Ovalbumin/immunology
MH  - Peptides/chemistry/immunology
MH  - Spleen/cytology/immunology
MH  - Strongyloides/immunology
MH  - Strongyloidiasis/immunology/parasitology
MH  - Th2 Cells/immunology
EDAT- 2009/05/26 09:00
MHDA- 2009/09/19 06:00
CRDT- 2009/05/26 09:00
PHST- 2008/12/16 00:00 [received]
PHST- 2009/04/14 00:00 [accepted]
PHST- 2009/05/26 09:00 [entrez]
PHST- 2009/05/26 09:00 [pubmed]
PHST- 2009/09/19 06:00 [medline]
AID - ni.1737 [pii]
AID - 10.1038/ni.1737 [doi]
PST - ppublish
SO  - Nat Immunol. 2009 Jul;10(7):706-12. doi: 10.1038/ni.1737. Epub 2009 May 24.