PMID- 19466545
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20211020
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 55
IP  - 4
DP  - 2010 Apr
TI  - Association of interleukin-18 gene polymorphisms with hepatitis B virus 
      clearance.
PG  - 1113-9
LID - 10.1007/s10620-009-0819-z [doi]
AB  - The outcome of hepatitis B virus (HBV) infection can be affected by host immune 
      factors. Interleukin-18 (IL-18) was originally discovered as an 
      interferon-gamma-inducing factor and plays a critical role in immune response. We 
      assessed the association between the clearance of HBV infection and 
      single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and 
      December 2004, a total of 1,050 Korean subjects were enrolled in the study and 
      divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) 
      the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic 
      sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C. 
      We observed that the subjects bearing the IL-18 -148C allele [odds ratio (OR), 
      0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 
      0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; 
      P = 0.01) were significantly associated with HBV clearance in a recessive model. 
      This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 
      gene are likely associated with HBV clearance in a Korean population.
FAU - Cheong, Jae Youn
AU  - Cheong JY
AD  - Department of Gastroenterology, Genomic Research Center for Gastroenterology, 
      Ajou University School of Medicine, San-5 Wonchon-Dong, Youngtong-ku, Suwon, 
      442-721, South Korea.
FAU - Cho, Sung Won
AU  - Cho SW
FAU - Oh, Bermseok
AU  - Oh B
FAU - Kimm, Kuchan
AU  - Kimm K
FAU - Lee, Kee Myung
AU  - Lee KM
FAU - Shin, Sung Jae
AU  - Shin SJ
FAU - Lee, Jung A
AU  - Lee JA
FAU - Park, Byung Lae
AU  - Park BL
FAU - Cheong, Hyun Sub
AU  - Cheong HS
FAU - Shin, Hyoung Doo
AU  - Shin HD
FAU - Cho, Bo Young
AU  - Cho BY
FAU - Kim, Jin Hong
AU  - Kim JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090523
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Carrier State/immunology
MH  - Chromosome Mapping
MH  - Confidence Intervals
MH  - Female
MH  - Genes, Recessive
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Hepatitis B/*genetics/*immunology
MH  - Humans
MH  - Immunogenetic Phenomena
MH  - Interleukin-18/*genetics
MH  - Linkage Disequilibrium/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prospective Studies
MH  - Remission, Spontaneous
MH  - Republic of Korea
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - Young Adult
EDAT- 2009/05/26 09:00
MHDA- 2010/04/03 06:00
CRDT- 2009/05/26 09:00
PHST- 2009/02/06 00:00 [received]
PHST- 2009/04/12 00:00 [accepted]
PHST- 2009/05/26 09:00 [entrez]
PHST- 2009/05/26 09:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 10.1007/s10620-009-0819-z [doi]
PST - ppublish
SO  - Dig Dis Sci. 2010 Apr;55(4):1113-9. doi: 10.1007/s10620-009-0819-z. Epub 2009 May 
      23.