PMID- 19466606
OWN - NLM
STAT- MEDLINE
DCOM- 20091229
LR  - 20240204
IS  - 0219-1032 (Electronic)
IS  - 1016-8478 (Linking)
VI  - 27
IP  - 5
DP  - 2009 May 31
TI  - ATG5 expression induced by MDMA (ecstasy), interferes with neuronal 
      differentiation of neuroblastoma cells.
PG  - 571-5
LID - 10.1007/s10059-009-0075-2 [doi]
AB  - The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a 
      popular recreational drug, and has also been shown to cause serotonergic 
      neurotoxicity. This report shows that MDMA impairs brain development in a whole 
      mouse embryo culture. The results of quantitative real-time PCR analysis showed 
      that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo 
      and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression 
      interferes with the neuronal differentiation of neuroblastoma cells such as 
      SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during 
      pregnancy may impair neuronal development via an induction of Atg5 expression.
FAU - Chae, Myounghee
AU  - Chae M
AD  - Korea Basic Science Institute, Gwangju Center, Gwangju 500-757, Korea.
FAU - Rhee, Gyu-Seek
AU  - Rhee GS
FAU - Jang, Ik-Soon
AU  - Jang IS
FAU - Kim, Kwangsoo
AU  - Kim K
FAU - Lee, Ji-Hae
AU  - Lee JH
FAU - Lee, Seung-Yeul
AU  - Lee SY
FAU - Kim, Minjung
AU  - Kim M
FAU - Yang, Junyoung
AU  - Yang J
FAU - Park, Junsoo
AU  - Park J
FAU - Lee, Seung-Hoon
AU  - Lee SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090515
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (ATG5 protein, human)
RN  - 0 (Atg5 protein, mouse)
RN  - 0 (Atg5 protein, rat)
RN  - 0 (Autophagy-Related Protein 5)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Proteins)
RN  - 5688UTC01R (Tretinoin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Autophagy/drug effects
MH  - Autophagy-Related Protein 5
MH  - Cell Differentiation/*drug effects
MH  - Embryo Culture Techniques
MH  - Female
MH  - Fetal Development/drug effects
MH  - Humans
MH  - Mice
MH  - Microtubule-Associated Proteins/*genetics/*metabolism
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neuroblastoma/metabolism/pathology
MH  - Neurons/*drug effects/metabolism/pathology
MH  - PC12 Cells
MH  - Pregnancy
MH  - Proteins/genetics/metabolism
MH  - Rats
MH  - Tretinoin/metabolism
EDAT- 2009/05/26 09:00
MHDA- 2009/12/30 06:00
CRDT- 2009/05/26 09:00
PHST- 2009/02/02 00:00 [received]
PHST- 2009/03/23 00:00 [accepted]
PHST- 2009/03/13 00:00 [revised]
PHST- 2009/05/26 09:00 [entrez]
PHST- 2009/05/26 09:00 [pubmed]
PHST- 2009/12/30 06:00 [medline]
AID - S1016-8478(23)13681-8 [pii]
AID - 10.1007/s10059-009-0075-2 [doi]
PST - ppublish
SO  - Mol Cells. 2009 May 31;27(5):571-5. doi: 10.1007/s10059-009-0075-2. Epub 2009 May 
      15.