PMID- 19468187
OWN - NLM
STAT- MEDLINE
DCOM- 20090828
LR  - 20090526
IS  - 1344-6304 (Print)
IS  - 1344-6304 (Linking)
VI  - 62
IP  - 3
DP  - 2009 May
TI  - Applicability of a monoclonal antibody-based stool antigen test to evaluate the 
      results of Helicobacter pylori eradication therapy.
PG  - 225-7
AB  - The (13)C-urea breath test (UBT) is widely used to examine the results of 
      eradication therapy for Helicobacter pylori. We examined whether a stool antigen 
      test can be used as efficiently as UBT. (i) Ninety-four patients infected with H. 
      pylori underwent eradication therapy. Six or eight weeks after the completion of 
      treatment, the results were evaluated by UBT and a stool antigen test (TPAg). In 
      77 out of 78 patients who had negative UBT results, the TPAg results were also 
      negative. Among the 16 UBT-positive patients, 12 were also positive by TPAg. 
      Agreement of UBT and TPAg was 94.7%. (ii) Twenty-two patients with peptic ulcers 
      in the active stage also received eradication therapy followed by proton pump 
      inhibitor (PPI) administration. TPAg and UBT were performed to examine the 
      results of eradication therapy at the end of PPI administration and at least 7 
      days after its discontinuation. Of the 22 patients taking PPIs, TPAg evaluated 
      the results of eradication therapy accurately in 21 patients. TPAg appears to be 
      an accurate test for evaluating the results of H. pylori eradication therapy, and 
      to be as efficient as (13)C-UBT. Use of the stool antigen test should be 
      considered as an alternative, particularly in patients who have to take PPIs in 
      order to avoid the risk of peptic ulcers.
FAU - Shimoyama, Tadashi
AU  - Shimoyama T
AD  - Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 
      Hirosaki 036-8562, Japan. tsimo-hki@umin.ac.jp
FAU - Kato, Chieko
AU  - Kato C
FAU - Kodama, Masaaki
AU  - Kodama M
FAU - Kobayashi, Intetsu
AU  - Kobayashi I
FAU - Fukuda, Yoshihiro
AU  - Fukuda Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Infect Dis
JT  - Japanese journal of infectious diseases
JID - 100893704
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Carbon Isotopes)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Anti-Ulcer Agents/therapeutic use
MH  - Antibodies, Monoclonal/immunology
MH  - Antigens, Bacterial/*analysis
MH  - Breath Tests
MH  - Carbon Isotopes
MH  - Duodenal Ulcer/drug therapy/microbiology
MH  - Feces/*microbiology
MH  - Helicobacter Infections/*drug therapy/microbiology
MH  - Helicobacter pylori/immunology/*isolation & purification
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Reproducibility of Results
MH  - Stomach Ulcer/drug therapy/microbiology
EDAT- 2009/05/27 09:00
MHDA- 2009/08/29 09:00
CRDT- 2009/05/27 09:00
PHST- 2009/05/27 09:00 [entrez]
PHST- 2009/05/27 09:00 [pubmed]
PHST- 2009/08/29 09:00 [medline]
PST - ppublish
SO  - Jpn J Infect Dis. 2009 May;62(3):225-7.