PMID- 19468758
OWN - NLM
STAT- MEDLINE
DCOM- 20100604
LR  - 20220311
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Mar
TI  - Determining the minimal clinically important difference criteria for the 
      Multidimensional Fatigue Inventory in a radiotherapy population.
PG  - 307-15
LID - 10.1007/s00520-009-0653-z [doi]
AB  - PURPOSE: The Multidimensional Fatigue Inventory (MFI) is a commonly used 
      cancer-related fatigue assessment tool. Unlike other fatigue assessments, there 
      are no published minimal clinically important difference (MCID) criteria for the 
      MFI in cancer populations. MCID criteria determine the smallest change in scores 
      that can be regarded as important, allowing clinicians and researchers to 
      interpret the meaning of changes in patient's fatigue scores. This research aims 
      to improve the clinical utility of the MFI by establishing MCID criteria for the 
      MFI sub-scales in a radiotherapy population. MATERIALS AND METHODS: Two hundred 
      ten patients undergoing radiotherapy were recruited to a single-centre 
      prospective cohort study. Patients were assessed at three time points, at the 
      start of radiotherapy, the end of radiotherapy and 6 weeks after radiotherapy 
      completion. Assessment consisted of four clinically relevant constructs: (1) 
      treatment impact on fatigue, (2) health-related quality of life, (3) performance 
      status and (4) occupational productivity. These constructs were used as external 
      or anchor-based measures to determine MCIDs for each sub-scale of the MFI. 
      RESULTS: Multiple MCIDs were identified, each from a different perspective based 
      on the constructs cited. Researchers seeking to use a generic MCID may wish to 
      use a two-point reference for each MFI sub-scale as it was consistent across the 
      pre- and post-radiotherapy comparison and occupational productivity anchors. 
      CONCLUSIONS: MCIDs validated in this study allow better interpretation of changes 
      in MFI sub-scale scores and allow effect size calculations for determining sample 
      size in future studies.
FAU - Purcell, Amanda
AU  - Purcell A
AD  - School of Health and Rehabilitation Sciences, The Univeristy of Queensland, St 
      Lucia, Brisbane 4067, Australia. amanda.purcell@uqconnect.edu.au
FAU - Fleming, Jennifer
AU  - Fleming J
FAU - Bennett, Sally
AU  - Bennett S
FAU - Burmeister, Bryan
AU  - Burmeister B
FAU - Haines, Terry
AU  - Haines T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20090526
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Cohort Studies
MH  - Employment
MH  - Fatigue/*classification/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/radiotherapy
MH  - Prospective Studies
MH  - Quality of Life
MH  - Radiotherapy/*adverse effects
EDAT- 2009/05/27 09:00
MHDA- 2010/06/05 06:00
CRDT- 2009/05/27 09:00
PHST- 2008/10/06 00:00 [received]
PHST- 2009/05/04 00:00 [accepted]
PHST- 2009/05/27 09:00 [entrez]
PHST- 2009/05/27 09:00 [pubmed]
PHST- 2010/06/05 06:00 [medline]
AID - 10.1007/s00520-009-0653-z [doi]
PST - ppublish
SO  - Support Care Cancer. 2010 Mar;18(3):307-15. doi: 10.1007/s00520-009-0653-z. Epub 
      2009 May 26.