PMID- 1946939
OWN - NLM
STAT- MEDLINE
DCOM- 19911223
LR  - 20211223
IS  - 0033-5622 (Print)
IS  - 0033-5622 (Linking)
VI  - 80
IP  - 291
DP  - 1991 Jul
TI  - Pulmonary hypertension in aortic regurgitation: early surgical outcome.
PG  - 589-95
AB  - A review of the haemodynamic data of 139 patients with isolated, severe, chronic 
      aortic regurgitation revealed severe pulmonary hypertension (pulmonary artery 
      systolic pressure of greater than or equal to 60 mmHg) in 34 (24 per cent). The 
      left ventricular end-diastolic pressure was high in all patients, suggesting that 
      pulmonary hypertension was a consequence of severe long-standing regurgitation 
      with ventricular dysfunction. Aortic valve replacement was performed in 69 
      patients, 33 of whom had normal or mildly elevated pulmonary artery systolic 
      pressure (less than 39 mmHg; group I) and 36 of whom had moderate or markedly 
      elevated pulmonary artery systolic pressures (less than 40 mmHg; group II). There 
      was no difference in mortality or prevalence of post-operative complications 
      between these two groups of patients. Furthermore, New York Heart Association 
      (NYHA) functional class and cardiothoracic ratio were similar in both groups at 
      the six-month assessment. The pulmonary vascular resistance fell from 4.7 +/- 3.5 
      to 1.5 +/- 0.8 units x m2 in 13 of 17 patients who had repeat catheterization 
      after surgery. Pulmonary artery systolic pressure reverted to normal in 10 of 
      these 13 patients. It is concluded that pulmonary hypertension consequent upon 
      raised left ventricular end-diastolic pressure is common in severe aortic 
      regurgitation, is largely reversible, and does not influence the early outcome 
      after aortic valve replacement.
FAU - Naidoo, D P
AU  - Naidoo DP
AD  - Department of Medicine, Faculty of Medicine, University of Natal, Durban, 
      Republic of South Africa.
FAU - Mitha, A S
AU  - Mitha AS
FAU - Vythilingum, S
AU  - Vythilingum S
FAU - Chetty, S
AU  - Chetty S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Q J Med
JT  - The Quarterly journal of medicine
JID - 0401027
SB  - IM
MH  - Adult
MH  - Aortic Valve Insufficiency/complications/physiopathology/*surgery
MH  - Chronic Disease
MH  - Female
MH  - *Heart Valve Prosthesis
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/etiology/physiopathology/*surgery
MH  - Male
MH  - Postoperative Period
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
PST - ppublish
SO  - Q J Med. 1991 Jul;80(291):589-95.