PMID- 19469898
OWN - NLM
STAT- MEDLINE
DCOM- 20091116
LR  - 20221207
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 18
IP  - 8
DP  - 2009 Aug
TI  - The Caucasian and African skin types differ morphologically and functionally in 
      their dermal component.
PG  - 704-11
LID - 10.1111/j.1600-0625.2009.00843.x [doi]
AB  - In the literature, most reported differences between African and Caucasian skin 
      properties concern pigmentation and barrier function of the stratum corneum and 
      related photoprotective properties. However, little is known about differences in 
      morphology and possibly related biological functions. In this study, we 
      investigated: (i) architectural differences of Caucasian and African mammary skin 
      biopsies using microscopy, (ii) comparative constitutive expression of cytokines, 
      matrix metalloproteinase 1 (MMP-1) and its inhibitors in papillary dermal 
      fibroblast (pF) and reticular dermal fibroblast (rF) cultures in order to reveal 
      biological features. (i) Neither epidermis thickness nor superficial dermis 
      thickness was significantly different in African versus Caucasian subjects. 
      However, the dermal-epidermal junction (DEJ) length in African skin was about 
      threefold that in Caucasian skin. No differences were noticed as regards elastic 
      and collagen fibre organization. (ii) In papillary fibroblast cultures, a 
      significantly higher level of monocyte chemotactic peptide-1 (MCP-1) protein was 
      found in cell cultures from African donors when compared with that from 
      Caucasians. With regard to keratinocyte growth factor (KGF), the ratio of 
      papillary to reticular fibroblast expression was found to be twofold greater in 
      cell cultures from African donors compared with that from Caucasian donors. The 
      same trend was found regarding MMP-1 and tissue inhibitor metalloproteinase 
      protein 1 (TIMP-1) protein expression. African skin displays a greater 
      convolution of the DEJ and a higher papillary fibroblast activity. These findings 
      reveal that differences between African and Caucasian skin do not only affect 
      upper epidermis but also dermal functions and dermal-epidermal cellular 
      interactions.
FAU - Girardeau, Sarah
AU  - Girardeau S
AD  - L'Oreal Research, 92583 Clichy cedex, France. sgirardeau@rd.loreal.com
FAU - Mine, Solene
AU  - Mine S
FAU - Pageon, Herve
AU  - Pageon H
FAU - Asselineau, Daniel
AU  - Asselineau D
LA  - eng
PT  - Journal Article
DEP - 20090312
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 126469-10-1 (Fibroblast Growth Factor 7)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Black People
MH  - Collagen/metabolism
MH  - Dermis/*pathology
MH  - Epidermis/*pathology
MH  - Female
MH  - Fibroblast Growth Factor 7/metabolism
MH  - Fibroblasts/*cytology
MH  - Humans
MH  - Matrix Metalloproteinase 1/metabolism
MH  - Middle Aged
MH  - Skin/*pathology
MH  - Tissue Inhibitor of Metalloproteinase-1/metabolism
MH  - White People
EDAT- 2009/05/28 09:00
MHDA- 2009/11/17 06:00
CRDT- 2009/05/28 09:00
PHST- 2009/05/28 09:00 [entrez]
PHST- 2009/05/28 09:00 [pubmed]
PHST- 2009/11/17 06:00 [medline]
AID - EXD843 [pii]
AID - 10.1111/j.1600-0625.2009.00843.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2009 Aug;18(8):704-11. doi: 10.1111/j.1600-0625.2009.00843.x. Epub 
      2009 Mar 12.