PMID- 19474282
OWN - NLM
STAT- MEDLINE
DCOM- 20091202
LR  - 20220316
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 24
IP  - 10
DP  - 2009 Oct
TI  - Alpha-lipoic acid attenuates cisplatin-induced acute kidney injury in mice by 
      suppressing renal inflammation.
PG  - 3012-20
LID - 10.1093/ndt/gfp242 [doi]
AB  - BACKGROUND: Cisplatin is a chemotherapeutic agent used in treatment of malignant 
      tumours. However, cisplatin produces various side effects, such as 
      nephrotoxicity, neurotoxicity, emetogenesis and ototoxicity. Inflammation is an 
      important mechanism of cisplatin nephrotoxicity. Alpha-lipoic acid (alpha-LA) has 
      anti-inflammatory effects that inhibit both adhesion molecule expression in human 
      endothelial cells and monocyte adhesion by suppressing the nuclear factor-kappaB 
      (NF-kappaB) signalling pathway. The goals of this study were to investigate the 
      anti-inflammatory effects of alpha-LA during cisplatin-induced renal injury and 
      to examine the mechanisms of protection. METHODS: C57BL/6 mice were given 
      cisplatin (20 mg/kg) with or without alpha-LA treatment (100 mg/kg for 3 days). 
      Renal function, histological changes, adhesion molecule expression and 
      inflammatory cell infiltration were examined. The effect of alpha-LA on NF-kappaB 
      activity was evaluated by examining nuclear translocation and phosphorylation of 
      NF-kappaB p65 subunits in kidney tissue. RESULTS: Cisplatin-induced decreases in 
      renal function, measured by blood urea nitrogen, serum creatinine level and renal 
      tubular injury scores, were attenuated by alpha-LA treatment. alpha-LA decreased 
      the tissue levels of tumour necrosis factor-alpha, the expression of 
      intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 
      (MCP-1), and suppressed the infiltration of CD11b-positive macrophages. alpha-LA 
      also attenuated the cisplatin-induced increases in the phosphorylation and 
      nuclear translocation of NF- kappaB p65 subunits in kidney tissue. CONCLUSIONS: 
      These results suggest that alpha-LA treatment ameliorates cisplatin-induced acute 
      kidney injury by reducing inflammatory adhesion molecule expression and NF-kappaB 
      activity.
FAU - Kang, Kyung Pyo
AU  - Kang KP
AD  - Department of Internal Medicine and Renal Regeneration Laboratory, Chonbuk 
      National University Medical School, Jeonju, Republic of Korea.
FAU - Kim, Duk Hoon
AU  - Kim DH
FAU - Jung, Yu Jin
AU  - Jung YJ
FAU - Lee, Ae Sin
AU  - Lee AS
FAU - Lee, Sik
AU  - Lee S
FAU - Lee, Sang Yong
AU  - Lee SY
FAU - Jang, Kyu Yun
AU  - Jang KY
FAU - Sung, Mi Jeong
AU  - Sung MJ
FAU - Park, Sung Kwang
AU  - Park SK
FAU - Kim, Won
AU  - Kim W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090527
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Antineoplastic Agents)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Acute Kidney Injury/*chemically induced/*prevention & control
MH  - Animals
MH  - Antineoplastic Agents/*adverse effects
MH  - Cisplatin/*adverse effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nephritis/*chemically induced/*prevention & control
MH  - Thioctic Acid/*therapeutic use
EDAT- 2009/05/29 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/05/29 09:00
PHST- 2009/05/29 09:00 [entrez]
PHST- 2009/05/29 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - gfp242 [pii]
AID - 10.1093/ndt/gfp242 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2009 Oct;24(10):3012-20. doi: 10.1093/ndt/gfp242. Epub 
      2009 May 27.