PMID- 19477513
OWN - NLM
STAT- MEDLINE
DCOM- 20100310
LR  - 20161125
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 34
IP  - 2
DP  - 2010 Feb
TI  - t(X;17) as the sole karyotypic anomaly in a case of M(3r) subtype of acute 
      promyelocytic leukemia without RARalpha rearrangement.
PG  - e55-7
LID - 10.1016/j.leukres.2009.04.034 [doi]
AB  - We describe here a unique chromosomal abnormality found in a patient with M(3r) 
      subtype of APL. Neither t(15;17) nor rearrangement of RARalpha was detected by 
      routine R-banded chromosome as well as fluorescence in situ hybridization (FISH) 
      analysis using PML/RARalpha dual-color dual-fusion translocation probe and 
      RARalpha dual-color break apart rearrangement probe. Instead of the typical 
      rearrangement between chromosomes 15 and 17, all cells analyzed had a 
      translocation between X and 17 as the sole karyotypic anomaly. The translocation 
      was conformed by whole chromosome painting (WCP) with painting probes of 
      chromosomes X and 17. To our knowledge, this is the first documented APL with a 
      novel translocation involving chromosomes X and 17 without RARalpha gene 
      rearrangement.
CI  - Copyright 2009. Published by Elsevier Ltd.
FAU - Wang, Huan-Ping
AU  - Wang HP
FAU - Xu, Huan
AU  - Xu H
FAU - Chen, Zhi-Mei
AU  - Chen ZM
FAU - Tong, Xiang-Min
AU  - Tong XM
FAU - Qian, Wen-Bin
AU  - Qian WB
FAU - Jin, Jie
AU  - Jin J
LA  - eng
PT  - Letter
DEP - 20090527
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
SB  - IM
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, X
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/classification/*genetics
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoic Acid Receptor alpha
MH  - *Translocation, Genetic
EDAT- 2009/05/30 09:00
MHDA- 2010/03/11 06:00
CRDT- 2009/05/30 09:00
PHST- 2009/04/19 00:00 [received]
PHST- 2009/04/21 00:00 [revised]
PHST- 2009/04/25 00:00 [accepted]
PHST- 2009/05/30 09:00 [entrez]
PHST- 2009/05/30 09:00 [pubmed]
PHST- 2010/03/11 06:00 [medline]
AID - S0145-2126(09)00226-4 [pii]
AID - 10.1016/j.leukres.2009.04.034 [doi]
PST - ppublish
SO  - Leuk Res. 2010 Feb;34(2):e55-7. doi: 10.1016/j.leukres.2009.04.034. Epub 2009 May 
      27.