PMID- 19477633
OWN - NLM
STAT- MEDLINE
DCOM- 20090911
LR  - 20220408
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 45
IP  - 12
DP  - 2009 Aug
TI  - Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer 
      and their associations with disease outcomes and expression of let-7a and IGF-II.
PG  - 2212-8
LID - 10.1016/j.ejca.2009.05.003 [doi]
AB  - Lin-28 and lin-28B are RNA-binding proteins which can block microRNA let-7 
      maturation and affect the differentiation and proliferation of embryonic stem 
      cells. Lin-28 may also regulate the expression of insulin-like growth factor II 
      (IGF-II). As one of the pluripotent factors involved in making induced 
      pluripotent stem cells (iPS), lin-28 is considered a potential therapeutic target 
      for cancer treatment. To further understand the role of lin-28 in cancer, we 
      analysed the expression of lin-28 and its homologue lin-28B in tumour samples, 
      and evaluated their associations with let-7a maturation, IGF-II expression, 
      disease features and outcomes in 211 patients with primary epithelial ovarian 
      cancer. The analysis showed that both lin-28 and lin-28B were positively 
      correlated with primary and pre-let-7a-3; lin-28B, not lin-28, was inversely 
      correlated with mature let-7a. A positive correlation was also observed between 
      lin-28B and IGF-II expression, while no association was found between lin-28B and 
      IGF-I or IGFBP-3. The study further demonstrated that lin-28B expression was 
      associated with the risk of disease progression and death; patients with high 
      lin-28B had shorter progression-free and overall survival than those with low 
      lin-28B. These results seem to support the findings of recent in vitro 
      experiments, showing that lin-28 blocks the process of let-7a maturation. Our 
      study also suggests that lin-28B may promote ovarian cancer progression and serve 
      as an unfavourable prognostic marker for the disease. The correlation between 
      lin-28B and IGF-II indicates that the growth factor may mediate the effect of 
      lin-28B on tumour growth.
FAU - Lu, Lingeng
AU  - Lu L
AD  - Department of Epidemiology and Public Health, Yale Cancer Center, Yale University 
      School of Medicine, 60 College Street, New Haven, CT 06520-8034, USA.
FAU - Katsaros, Dionyssios
AU  - Katsaros D
FAU - Shaverdashvili, Khvaramze
AU  - Shaverdashvili K
FAU - Qian, Biyun
AU  - Qian B
FAU - Wu, Yixing
AU  - Wu Y
FAU - de la Longrais, Irene A Rigault
AU  - de la Longrais IA
FAU - Preti, Mario
AU  - Preti M
FAU - Menato, Guido
AU  - Menato G
FAU - Yu, Herbert
AU  - Yu H
LA  - eng
GR  - R01 CA098346/CA/NCI NIH HHS/United States
GR  - N02-CO-41101/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090526
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (LIN28B protein, human)
RN  - 0 (Lin28A protein, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (mirnlet7 microRNA, human)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor II/genetics/*metabolism
MH  - MicroRNAs/*metabolism
MH  - Ovarian Neoplasms/genetics/*metabolism/therapy
MH  - Pluripotent Stem Cells/*metabolism
MH  - RNA-Binding Proteins/genetics/*metabolism
MH  - Survival Analysis
EDAT- 2009/05/30 09:00
MHDA- 2009/09/12 06:00
CRDT- 2009/05/30 09:00
PHST- 2009/03/04 00:00 [received]
PHST- 2009/04/28 00:00 [revised]
PHST- 2009/05/01 00:00 [accepted]
PHST- 2009/05/30 09:00 [entrez]
PHST- 2009/05/30 09:00 [pubmed]
PHST- 2009/09/12 06:00 [medline]
AID - S0959-8049(09)00343-8 [pii]
AID - 10.1016/j.ejca.2009.05.003 [doi]
PST - ppublish
SO  - Eur J Cancer. 2009 Aug;45(12):2212-8. doi: 10.1016/j.ejca.2009.05.003. Epub 2009 
      May 26.