PMID- 19477875
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20090902
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 30
IP  - 17
DP  - 2009 Sep
TI  - Left ventricular dyssynchrony in patients with left bundle branch block and 
      patients after myocardial infarction: integration of mechanics and viability by 
      cardiac magnetic resonance.
PG  - 2117-27
LID - 10.1093/eurheartj/ehp212 [doi]
AB  - AIMS: To quantify left ventricular (LV) dyssynchrony in patients with left bundle 
      branch block (LBBB) and in patients after myocardial infarction (MI) applying an 
      accelerated three-dimensional (3D) tagging cardiac magnetic resonance (CMR) 
      technique, and to combine dyssynchrony information with viability data obtained 
      by late gadolinium enhancement (LGE) CMR. METHODS AND RESULTS: Thirty-two 
      patients (59 +/- 11 years) after first MI (Pats(MI)), 10 patients (63 +/- 10 
      years) with LBBB (ejection fraction < 40%; Pats(LBBB<40)), 13 patients (63 +/- 
      11) with LBBB (ejection fraction >or= 40%; Pats(LBBB >or=40 )), and 15 healthy 
      controls (53 +/- 10 years) underwent 3D tagging CMR and LGE imaging at 1.5 T. As 
      a measure of mechanical LV dyssynchrony, the standard deviation of T(max) over 
      the LV, the circumferential uniformity ratio estimate (CURE) index, and a 
      segmental-based circumferential systolic dyssynchrony index (SDI) were 
      calculated. All three parameters detected significantly increased circumferential 
      dyssynchrony in patients compared with controls. The CURE and SDI showed a good 
      correlation (r = 0.93, P < 0.0001) and detected most severe dyssynchrony in 
      Pats(LBBB<40) (P < 0.001 vs. controls, P < 0.005 vs. Pats(MI)). Systolic 
      dyssynchrony index additionally allowed integration of localized viability 
      information to yield SDI(viable) which was highest in Pats(LBBB<40). CONCLUSION: 
      Dyssynchrony patterns in the LV can be quantified globally and regionally by 3D 
      tagging CMR. Combination of viability and dyssynchrony information allows for a 
      comprehensive dyssynchrony quantification in patients with LBBB or post-MI. 
      Future studies are required to test the value of the method to predict 
      responsiveness to resynchronization.
FAU - Rutz, Andrea K
AU  - Rutz AK
AD  - Institute for Biomedical Engineering, University and ETH Zurich, Zurich, 
      Switzerland.
FAU - Manka, Robert
AU  - Manka R
FAU - Kozerke, Sebastian
AU  - Kozerke S
FAU - Roas, Susanne
AU  - Roas S
FAU - Boesiger, Peter
AU  - Boesiger P
FAU - Schwitter, Juerg
AU  - Schwitter J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090528
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bundle-Branch Block/*etiology/pathology/physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*complications/pathology/physiopathology
MH  - Observer Variation
MH  - Ventricular Dysfunction, Left/*etiology/pathology/physiopathology
EDAT- 2009/05/30 09:00
MHDA- 2010/06/19 06:00
CRDT- 2009/05/30 09:00
PHST- 2009/05/30 09:00 [entrez]
PHST- 2009/05/30 09:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - ehp212 [pii]
AID - 10.1093/eurheartj/ehp212 [doi]
PST - ppublish
SO  - Eur Heart J. 2009 Sep;30(17):2117-27. doi: 10.1093/eurheartj/ehp212. Epub 2009 
      May 28.