PMID- 19478209
OWN - NLM
STAT- MEDLINE
DCOM- 20090819
LR  - 20161122
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 40
IP  - 8
DP  - 2009 Aug
TI  - Dietary protein, but not carbohydrate, is a primary determinant of the onset of 
      stroke in stroke-prone spontaneously hypertensive rats.
PG  - 2828-35
LID - 10.1161/STROKEAHA.109.555383 [doi]
AB  - BACKGROUND AND PURPOSE: Previously, an inverse association has been found between 
      the dietary proportion of protein or fat and incidence of intracerebral 
      hemorrhage. A positive association has been found with respect to carbohydrate 
      intake. To examine what changes in macronutrient intake are causative, animal 
      studies were conducted. METHODS: Stroke-prone spontaneously hypertensive rats 
      (SHRSP) were fed diets with varying ratios of macronutrients ad libitum, and the 
      onset of stroke was examined. RESULTS: When 10% of calories were from fat, rats 
      fed a high-protein/low-carbohydrate diet (55% calories from protein) had a 
      delayed onset of stroke, whereas rats fed a low-protein/high-carbohydrate diet 
      (5% calories from protein) had an accelerated onset of stroke. When 30% of 
      calories were from carbohydrate, a marked delay in the onset of stroke was 
      observed when the diet was high in protein. When 85% of calories were from 
      carbohydrate, rats fed 7.5% of calories as protein displayed an accelerated onset 
      of stroke. When 20% of calories were from protein, increased fat content did not 
      affect the onset of stroke. However, with a fat-free diet, when 20% of calories 
      were from protein, the onset of stroke was delayed, whereas when 10% of calories 
      were from protein, the onset of stroke was accelerated. CONCLUSIONS: The amount 
      of protein, but not of carbohydrate and fat, is a primary determinant of the 
      onset of stroke. However, when calories from protein are relatively low in the 
      diet (10%), fat is necessary to delay the onset of stroke in SHRSP.
FAU - Chiba, Tsuyoshi
AU  - Chiba T
AD  - Nutritional Science Program, National Institute of Health and Nutrition, 1-23-1 
      Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan.
FAU - Itoh, Tatsuki
AU  - Itoh T
FAU - Tabuchi, Masaki
AU  - Tabuchi M
FAU - Satou, Takao
AU  - Satou T
FAU - Ezaki, Osamu
AU  - Ezaki O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090528
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Animals
MH  - Body Weight/physiology
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Dietary Proteins/*administration & dosage/*adverse effects
MH  - Eating/physiology
MH  - Hypertension/*complications/physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Stroke/*etiology/physiopathology
EDAT- 2009/05/30 09:00
MHDA- 2009/08/20 09:00
CRDT- 2009/05/30 09:00
PHST- 2009/05/30 09:00 [entrez]
PHST- 2009/05/30 09:00 [pubmed]
PHST- 2009/08/20 09:00 [medline]
AID - STROKEAHA.109.555383 [pii]
AID - 10.1161/STROKEAHA.109.555383 [doi]
PST - ppublish
SO  - Stroke. 2009 Aug;40(8):2828-35. doi: 10.1161/STROKEAHA.109.555383. Epub 2009 May 
      28.