PMID- 19480261
OWN - NLM
STAT- MEDLINE
DCOM- 20090617
LR  - 20200929
IS  - 0392-2936 (Print)
IS  - 0392-2936 (Linking)
VI  - 30
IP  - 2
DP  - 2009
TI  - A case of HMB45-negative perivascular epithelioid cell tumor (PEComa) of the 
      uterine corpus: a possible diagnostic application of molecular-cytogenetic 
      analysis.
PG  - 216-9
AB  - We report a case of uterine angiomyolipoma confirmed with molecular-genetic 
      analysis by fluorescence in situ hybridization (FISH). A 25-year-old nulliparous 
      woman visited Yamaguchi University Hospital with a complaint of lower abdominal 
      pain. Magnetic resonance imaging demonstrated an ill-bordered uterine tumor and 
      exploratory laparotomy revealed a myometrial elastic-soft tumor at the anterior 
      wall of the uterine corpus. Histopathologically, the tumor consisted of fascicles 
      of smooth muscle cells with intermingled adipocytes and small to medium-sized 
      arterial blood vessels surrounded by epithelioid cells of clear cytoplasm. FISH 
      examination revealed chromosome X trisomy, which was comparable to a previously 
      reported molecular-genetic finding of PEComa family tumors including 
      angiomyolipoma. Although the tumor was immunohistochemically negative for HMB-45 
      antigen, the histological and FISH findings were compatible with angiomyolipoma.
FAU - Yamagata, Y
AU  - Yamagata Y
AD  - Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of 
      Medicine, Ube, Japan. yymgt@yamaguchi-u.ac.jp
FAU - Kawauchi, S
AU  - Kawauchi S
FAU - Tamura, H
AU  - Tamura H
FAU - Murakami, A
AU  - Murakami A
FAU - Sasaki, K
AU  - Sasaki K
FAU - Sugino, N
AU  - Sugino N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Singapore
TA  - Eur J Gynaecol Oncol
JT  - European journal of gynaecological oncology
JID - 8100357
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Melanoma-Specific Antigens)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adult
MH  - Angiomyolipoma/diagnosis/immunology/pathology
MH  - Antigens, Neoplasm/*analysis
MH  - Biomarkers, Tumor/*analysis
MH  - Chromosomes, Human, X/genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Melanoma-Specific Antigens
MH  - Neoplasm Proteins/*analysis
MH  - Perivascular Epithelioid Cell Neoplasms/*diagnosis/immunology/pathology
MH  - Trisomy
MH  - Uterine Neoplasms/*diagnosis/immunology/pathology
EDAT- 2009/06/02 09:00
MHDA- 2009/06/18 09:00
CRDT- 2009/06/02 09:00
PHST- 2009/06/02 09:00 [entrez]
PHST- 2009/06/02 09:00 [pubmed]
PHST- 2009/06/18 09:00 [medline]
PST - ppublish
SO  - Eur J Gynaecol Oncol. 2009;30(2):216-9.