PMID- 19480848
OWN - NLM
STAT- MEDLINE
DCOM- 20090925
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 4
DP  - 2009 Apr
TI  - TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically 
      homogenous Chinese Han population.
PG  - 257-61
LID - 10.1016/j.humimm.2009.01.028 [doi]
AB  - Human leukocyte antigen (HLA)-B27 is strongly associated with the autoimmune 
      disease ankylosing spondylitis (AS). Other autoimmune disease-associated genes, 
      such as transporter associated with antigen processing (TAP) genes, could also 
      influence AS susceptibility. In this study, we investigated the association of 
      TAP1 and TAP2 polymorphisms in genetically homogenous Chinese AS patients. Six 
      TAP1 single nucleotide polymorphisms (SNPs) and three TAP2 SNPs sites were 
      analyzed in B27-positive AS cases, healthy B27-negative controls, and healthy 
      B27-positive controls. In the allele and genotype analysis, the results indicated 
      that TAP1 site 1910 allele G, genotype AG and TAP2 site 1693 genotype AA were 
      associated with increased AS risk in a case-B27 negative control (p < 0.05). In 
      the haplotype analysis, TAP1 SNP haplotype (GGGGGG, TAP1*020101) and TAP1-TAP2 
      SNP haplotypes (GGGGGG-GGG, TAP1*020101-TAP2*0101, and GGAAGG-GAG, 
      TAP1*0101-TAP2*0102) increased AS risk in case-B27 negative control (p < 0.05). 
      In contrast, TAP1-TAP2 SNP haplotype GGGGGG-GAG (TAP1*020101-TAP2*0102) was less 
      common in cases than in B27-negative controls (p < 0.05). Moreover, TAP1-TAP2 SNP 
      haplotype GGGAGG-GGG (TAP1*0301-TAP2*0101) was less common in cases than in 
      B27-positive controls. The two haplotypes appeared to confer protection in AS (p 
      < 0.05). These results suggest a potential mechanism of altered antigen-peptide 
      selection and transport in AS pathogenesis.
FAU - Feng, Mingliang
AU  - Feng M
AD  - Shanghai Blood Center, Shanghai, People's Republic of China. 
      fengmingliang@sbc.org.cn
FAU - Yin, Biao
AU  - Yin B
FAU - Shen, Tong
AU  - Shen T
FAU - Ma, Qing
AU  - Ma Q
FAU - Liu, Lidong
AU  - Liu L
FAU - Zheng, Jiewei
AU  - Zheng J
FAU - Zhao, Yulin
AU  - Zhao Y
FAU - Qian, Kaicheng
AU  - Qian K
FAU - Liu, Dazhuang
AU  - Liu D
LA  - eng
PT  - Journal Article
DEP - 20090204
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (TAP1 protein, human)
RN  - 145892-13-3 (TAP2 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - Chi-Square Distribution
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-B27 Antigen/immunology
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Sequence Analysis, DNA
MH  - Spondylitis, Ankylosing/ethnology/*genetics/immunology
EDAT- 2009/06/02 09:00
MHDA- 2009/09/26 06:00
CRDT- 2009/06/02 09:00
PHST- 2008/10/10 00:00 [received]
PHST- 2009/01/16 00:00 [revised]
PHST- 2009/01/28 00:00 [accepted]
PHST- 2009/06/02 09:00 [entrez]
PHST- 2009/06/02 09:00 [pubmed]
PHST- 2009/09/26 06:00 [medline]
AID - S0198-8859(09)00040-8 [pii]
AID - 10.1016/j.humimm.2009.01.028 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Apr;70(4):257-61. doi: 10.1016/j.humimm.2009.01.028. Epub 2009 
      Feb 4.