PMID- 19480851
OWN - NLM
STAT- MEDLINE
DCOM- 20090925
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 4
DP  - 2009 Apr
TI  - High-resolution human leukocyte antigen (HLA) haplotypes and linkage 
      disequilibrium of HLA-B and -C and HLA-DRB1 and -DQB1 alleles in a Taiwanese 
      population.
PG  - 269-76
LID - 10.1016/j.humimm.2009.01.015 [doi]
AB  - Using the maximum-likelihood method with the expectation-maximization (EM) 
      algorithm of PYPOP, high-resolution human leukocyte antigen (HLA) three-locus 
      haplotypes (HLA-A, -B, and -C; HLA-A, -B, and -DRB1) and four-locus haplotypes 
      (HLA-A, -B, -C, and -DRB1) were determined. Linkage disequilibrium of 
      high-resolution HLA-B and -C alleles and HLA-DRB1 and -DQB1 alleles was also 
      calculated. Comparison of the Taiwanese haplotypes and haplotypes from donors in 
      the Chinese Han population, the Asia Pacific Islander ethnic category of the NMDP 
      (National Marrow Donor Program), and the Taiwanese cord blood units demonstrated 
      similarities and dissimilarities among the four populations. HLA allele 
      frequencies of our study suggested that the Taiwanese have a relative population 
      relationship with the southern Han Chinese with regard to HLA. Our results also 
      indicated that the Taiwanese population exhibits genetic proximity with Asian 
      Americans with regard to HLA-A and -DRB1 but not HLA-B.
FAU - Yang, Kuo-Liang
AU  - Yang KL
AD  - Laboratory of Immunogenetics and Cord Blood Bank, Tzu Chi Taiwan Marrow Donor 
      Registry, Buddhist Tzu Chi Hospital, Hualien 970, Taiwan. edward@tzuchi.com.tw
FAU - Chen, Shee-Ping
AU  - Chen SP
FAU - Shyr, Ming-Huang
AU  - Shyr MH
FAU - Lin, Py-Yu
AU  - Lin PY
LA  - eng
PT  - Journal Article
DEP - 20090221
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Algorithms
MH  - Alleles
MH  - Asian People/genetics
MH  - Gene Frequency
MH  - Genetics, Population
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Taiwan
EDAT- 2009/06/02 09:00
MHDA- 2009/09/26 06:00
CRDT- 2009/06/02 09:00
PHST- 2008/09/14 00:00 [received]
PHST- 2009/01/21 00:00 [revised]
PHST- 2009/01/22 00:00 [accepted]
PHST- 2009/06/02 09:00 [entrez]
PHST- 2009/06/02 09:00 [pubmed]
PHST- 2009/09/26 06:00 [medline]
AID - S0198-8859(09)00020-2 [pii]
AID - 10.1016/j.humimm.2009.01.015 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Apr;70(4):269-76. doi: 10.1016/j.humimm.2009.01.015. Epub 2009 
      Feb 21.