PMID- 19482646
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20220224
IS  - 1945-0508 (Electronic)
IS  - 1945-0494 (Linking)
VI  - 1
IP  - 1
DP  - 2009 Jun 1
TI  - Immunomodulatory effects of chemokines during the early implantation window.
PG  - 288-98
AB  - Successful implantation requires a functionally normal embryo at the blastocyst 
      stage and a receptive endometrium as well as adequate communication between them 
      throughout the implantation process. This cross-talk is highly regulated by a 
      number of different kinds of molecules. Particularly, chemokines, small 
      polypeptides that attract specific leukocyte subsets by binding to cell-surface 
      receptors, are also required to maintain immune-privileged sites as the 
      feto-maternal interface. Chemokines expression involves an interdependent network 
      with the absence of a single chemokine affecting the expression of multiple other 
      chemokines, we have chosen to focus on just two representative examples: RANTES 
      (regulated on normal T cell expressed and secreted) and MCP-1 (Monocyte 
      chemo-attractant protein). Here, we present updated information on their 
      expression levels and regulation on three different levels: 1) systemic effects 
      on maternal allogeneic response; 2) local effects on endometrial cells; and 3) 
      during an early stage of the feto-maternal dialogue. For each of the three 
      levels, we analyzed data from both fertile women and patients having experienced 
      recurrent spontaneous abortions as representative of physiological and 
      pathological situations respectively.
FAU - Fraccaroli, Laura
AU  - Fraccaroli L
AD  - Immunopharmacology Laboratory, School of Exact and Natural Sciences, Int. 
      Guiraldes 2160, Ciudad Universitaria, Pabellon 2 Piso 4, (C1428EHA) University of 
      Buenos Aires, Argentina.
FAU - Alfieri, Julio
AU  - Alfieri J
FAU - Leiros, Claudia Perez
AU  - Leiros CP
FAU - Ramhorst, Rosanna
AU  - Ramhorst R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090601
PL  - Singapore
TA  - Front Biosci (Elite Ed)
JT  - Frontiers in bioscience (Elite edition)
JID - 101485240
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Abortion, Habitual/*immunology
MH  - Chemokine CCL5/metabolism/pharmacology
MH  - Chemokines/immunology/*metabolism
MH  - Embryo Implantation/*immunology
MH  - Endometrium/cytology/*metabolism
MH  - Female
MH  - Histocompatibility, Maternal-Fetal/drug effects/*immunology
MH  - Humans
MH  - Immunologic Factors/immunology/*metabolism
MH  - Maternal-Fetal Exchange/*immunology
MH  - Pregnancy
MH  - T-Lymphocytes/metabolism
RF  - 57
EDAT- 2009/06/02 09:00
MHDA- 2010/06/17 06:00
CRDT- 2009/06/02 09:00
PHST- 2009/06/02 09:00 [entrez]
PHST- 2009/06/02 09:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 28 [pii]
AID - 10.2741/E28 [doi]
PST - epublish
SO  - Front Biosci (Elite Ed). 2009 Jun 1;1(1):288-98. doi: 10.2741/E28.