PMID- 19482867
OWN - NLM
STAT- MEDLINE
DCOM- 20090821
LR  - 20111117
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 15
IP  - 6
DP  - 2009 Jun
TI  - Protective role of the HLA-A*02 allele in Portuguese patients with multiple 
      sclerosis.
PG  - 771-4
LID - 10.1177/1352458509104588 [doi]
AB  - BACKGROUND: Multiple sclerosis (MS) is associated with human leukocyte antigen 
      (HLA) HLA-DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests 
      that HLA class I may also contribute. An association of HLA-A*02 and A*03 alleles 
      has been described. OBJECTIVES: We examined the influence of HLA-A*02 and 
      HLA-A*03 in Portuguese patients with MS, independently of HLA-DRB1*15 using a 
      logistic regression model. CONCLUSIONS: DRB1*15 increased the risk of developing 
      MS and HLA-A*02 decreased the risk. A*03 had no effect. To analyze if HLA-A*02 
      association was independent from DRB1*15, an interaction between these two 
      alleles was introduced in the model; no significant interaction was found.
FAU - Silva, A M
AU  - Silva AM
AD  - Departamento de Neurologia, Centro Hospitalar do Porto-Hospital de Santo Antonio, 
      Porto, Portugal. anadmsilva@yahoo.com
FAU - Bettencourt, A
AU  - Bettencourt A
FAU - Pereira, C
AU  - Pereira C
FAU - Santos, E
AU  - Santos E
FAU - Carvalho, C
AU  - Carvalho C
FAU - Mendonca, D
AU  - Mendonca D
FAU - Costa, P P
AU  - Costa PP
FAU - Monteiro, L
AU  - Monteiro L
FAU - Martins, B
AU  - Martins B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*02 antigen)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15 antigen)
SB  - IM
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Genetic Predisposition to Disease/epidemiology
MH  - HLA-A Antigens/*genetics
MH  - HLA-A2 Antigen
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Logistic Models
MH  - Multiple Sclerosis/*epidemiology/*genetics/immunology
MH  - Phenotype
MH  - Portugal/epidemiology
MH  - Risk Factors
EDAT- 2009/06/02 09:00
MHDA- 2009/08/22 09:00
CRDT- 2009/06/02 09:00
PHST- 2009/06/02 09:00 [entrez]
PHST- 2009/06/02 09:00 [pubmed]
PHST- 2009/08/22 09:00 [medline]
AID - 15/6/771 [pii]
AID - 10.1177/1352458509104588 [doi]
PST - ppublish
SO  - Mult Scler. 2009 Jun;15(6):771-4. doi: 10.1177/1352458509104588.