PMID- 19483327
OWN - NLM
STAT- MEDLINE
DCOM- 20090724
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 32
IP  - 6
DP  - 2009 Jun
TI  - Ellagic Acid attenuates immunoglobulin E-mediated allergic response in mast 
      cells.
PG  - 1118-21
AB  - Ellagic acid is known to have anti-oxidant, anti-carcinogenic and anti-mutagenic 
      effects. However, roles of ellagic acid in the immediate-type allergic reactions 
      have not yet been investigated. In the present study, we have demonstrated that 
      ellagic acid attenuates immunoglobulin (Ig)E-mediated allergic response in mast 
      cells and in vivo. Oral administration of ellagic acid inhibited 
      anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis. Ellagic acid 
      dose-dependently reduced histamine release and the expression and secretion of 
      pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6 
      in rat peritoneal mast cells (RPMC) activated by anti-DNP IgE. Moreover, ellagic 
      acid suppressed an increase in intracellular calcium ion concentration 
      ([Ca(2+)](i)) in RPMC. Furthermore, ellagic acid decreased the activation of 
      nuclear factor-kappa B (NF-kappaB). Decreased NF-kappaB activity as well as 
      reduced [Ca(2+)](i) might be involved in the inhibitory effect of ellagic acid on 
      the secretory response. Our findings provide possibility that ellagic acid may 
      serve as an effective therapeutic agent for allergic diseases.
FAU - Choi, Yun Ho
AU  - Choi YH
AD  - Department of Anatomy, Chonbuk National University Medical School, Jeonbuk, 
      Republic of Korea.
FAU - Yan, Guang Hai
AU  - Yan GH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Antigens)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 19YRN3ZS9P (Ellagic Acid)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/chemistry/*pharmacology
MH  - Antigens/immunology
MH  - Calcium/metabolism
MH  - Cell Nucleus/metabolism
MH  - Cells, Cultured
MH  - Cytosol/metabolism
MH  - Disease Models, Animal
MH  - Ellagic Acid/chemistry/*pharmacology
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/immunology/*prevention & control
MH  - Immunoglobulin E/*immunology
MH  - Interleukin-6/immunology
MH  - Male
MH  - Mast Cells/*drug effects/immunology
MH  - Molecular Structure
MH  - NF-kappa B/biosynthesis
MH  - Passive Cutaneous Anaphylaxis/*drug effects/immunology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/immunology
EDAT- 2009/06/02 09:00
MHDA- 2009/07/25 09:00
CRDT- 2009/06/02 09:00
PHST- 2009/06/02 09:00 [entrez]
PHST- 2009/06/02 09:00 [pubmed]
PHST- 2009/07/25 09:00 [medline]
AID - JST.JSTAGE/bpb/32.1118 [pii]
AID - 10.1248/bpb.32.1118 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2009 Jun;32(6):1118-21. doi: 10.1248/bpb.32.1118.