PMID- 19484970
OWN - NLM
STAT- MEDLINE
DCOM- 20091001
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 48
IP  - 1
DP  - 2009 Jan
TI  - [Multiple endocrine neoplasia type 1 presenting as hypoglycemic coma: a report of 
      four cases and review of literatures].
PG  - 13-6
AB  - OBJECTIVE: To investigate the clinical characteristics of multiple endocrine 
      neoplasia type 1 (MEN1) patients presenting with hypoglycemic coma as chief 
      manifestation and the related clinical experience in diagnosis and therapy. 
      METHODS: We analyzed the clinical data of 4 patients who were hospitalized 
      because of recurrent hypoglycemic coma and diagnosed as having MEN1 by 
      endocrinological, radiological and pathological examinations. RESULTS: In the 4 
      cases of Whipple trilogy, radiological examination showed occupying lesion in the 
      pancreas and pathological examination confirmed the diagnosis of insulinoma. In 2 
      cases the insulinomas were multiple. In this series, one case was complicated 
      with pituitary adenoma, parathyroidoma (recurrent after operation) and 
      adrenocortical adenoma, one case with pituitary adenoma, parathyroidoma (2 
      tumors) and adrenal nodular hyperplasia, one case with pituitary adenoma and 
      parathyroidoma, and the remaining one with pituitary adenoma and suspectible 
      parathyroidoma. CONCLUSIONS: For patients with insulinoma, MEN1 should be 
      considered. In patients with MEN1, the presence of multiple or ectopic 
      parathyroid adenomas (or hyperplasia) and insulinomas should be inspected during 
      operation. After operation, examinations should be regularly performed to 
      identify whether the diseases relapse or new endocrine neoplasias occur.
FAU - Wang, Xian-ling
AU  - Wang XL
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Lu, Ju-ming
AU  - Lu JM
FAU - Dou, Jing-tao
AU  - Dou JT
FAU - Mu, Yi-ming
AU  - Mu YM
FAU - Lu, Zhao-hui
AU  - Lu ZH
FAU - Guo, Qing-hua
AU  - Guo QH
FAU - Ba, Jian-ming
AU  - Ba JM
FAU - Pan, Chang-yu
AU  - Pan CY
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adult
MH  - Coma/diagnosis/*etiology
MH  - Female
MH  - Humans
MH  - Hypoglycemia/diagnosis/*etiology
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*complications/diagnosis
MH  - Pancreatic Neoplasms/complications/diagnosis
MH  - Parathyroid Neoplasms/complications/diagnosis
MH  - Pituitary Neoplasms/complications/diagnosis
MH  - Young Adult
RF  - 8
EDAT- 2009/06/03 09:00
MHDA- 2009/10/02 06:00
CRDT- 2009/06/03 09:00
PHST- 2009/06/03 09:00 [entrez]
PHST- 2009/06/03 09:00 [pubmed]
PHST- 2009/10/02 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2009 Jan;48(1):13-6.