PMID- 19485844
OWN - NLM
STAT- MEDLINE
DCOM- 20090811
LR  - 20201219
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 190
IP  - 11
DP  - 2009 Jun 1
TI  - Improving drug safety by locating genetic markers for hypersensitivity reactions.
PG  - 641-3
AB  - Individuals vary in their response to a medication with regard to efficacy and 
      adverse effects. The human leukocyte antigen (HLA) region of DNA offers the key 
      to predicting drug hypersensitivity reactions. Single nucleotide polymorphisms 
      for hypersensitivity reactions with carbamazepine, abacavir and allopurinol have 
      been identified. A randomised controlled trial demonstrated the effectiveness of 
      prospective screening for the predisposing genetic marker in preventing all cases 
      of the hypersensitivity reaction with abacavir. Further pharmacogenetic 
      investigation of hypersensitivity reactions could be conducted in Australia by 
      establishing a network of sentinel hospitals.
FAU - Ronaldson, Kathlyn J
AU  - Ronaldson KJ
AD  - Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 
      VIC. kathlyn.ronaldson@med.monash.edu.au
FAU - McNeil, John J
AU  - McNeil JJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
RN  - 0 (Biomarkers, Pharmacological)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Biomarkers, Pharmacological/*analysis
MH  - Drug Hypersensitivity/diagnosis/*genetics
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Genetic Markers/*genetics
MH  - Humans
MH  - Hypersensitivity, Delayed/diagnosis/*genetics
MH  - Hypersensitivity, Immediate/diagnosis/*genetics
MH  - Pharmacogenetics/*methods
RF  - 23
EDAT- 2009/06/03 09:00
MHDA- 2009/08/12 09:00
CRDT- 2009/06/03 09:00
PHST- 2008/05/20 00:00 [received]
PHST- 2008/11/19 00:00 [accepted]
PHST- 2009/06/03 09:00 [entrez]
PHST- 2009/06/03 09:00 [pubmed]
PHST- 2009/08/12 09:00 [medline]
AID - ron10621_fm [pii]
AID - 10.5694/j.1326-5377.2009.tb02594.x [doi]
PST - ppublish
SO  - Med J Aust. 2009 Jun 1;190(11):641-3. doi: 10.5694/j.1326-5377.2009.tb02594.x.