PMID- 19489765
OWN - NLM
STAT- MEDLINE
DCOM- 20091020
LR  - 20220318
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 98
IP  - 9
DP  - 2009 Sep
TI  - Fish oil supplementation in pregnancy and lactation may decrease the risk of 
      infant allergy.
PG  - 1461-7
LID - 10.1111/j.1651-2227.2009.01355.x [doi]
AB  - Maternal intake of omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) during 
      pregnancy has decreased, possibly contributing to a current increased risk of 
      childhood allergy. AIM: To describe the effects of maternal omega-3 long-chain 
      PUFA supplementation during pregnancy and lactation on the incidence of allergic 
      disease in infancy. METHODS: One hundred and forty-five pregnant women, affected 
      by allergy themselves or having a husband or previous child with allergies, were 
      included in a randomized placebo-controlled trial. Daily maternal supplementation 
      with either 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid or placebo 
      was given from the 25(th) gestational week to average 3-4 months of 
      breastfeeding. Skin prick tests, detection of circulating specific immunoglobulin 
      E (IgE) antibodies and clinical examinations of the infants were performed. 
      RESULTS: The period prevalence of food allergy was lower in the omega-3 group 
      (1/52, 2%) compared to the placebo group (10/65, 15%, p < 0.05) as well as the 
      incidence of IgE-associated eczema (omega-3 group: 4/52, 8%; placebo group: 
      15/63, 24%, p < 0.05). CONCLUSION: Maternal omega-3 fatty acid supplementation 
      may decrease the risk of food allergy and IgE-associated eczema during the first 
      year of life in infants with a family history of allergic disease.
FAU - Furuhjelm, Catrin
AU  - Furuhjelm C
AD  - Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty 
      of Health Sciences, Linkoping University, Linkoping, Sweden. 
      catrin.furuhjelm@lio.se
FAU - Warstedt, Kristina
AU  - Warstedt K
FAU - Larsson, Johanna
AU  - Larsson J
FAU - Fredriksson, Mats
AU  - Fredriksson M
FAU - Bottcher, Malin Fageras
AU  - Bottcher MF
FAU - Falth-Magnusson, Karin
AU  - Falth-Magnusson K
FAU - Duchen, Karel
AU  - Duchen K
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20090601
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Fatty Acids, Omega-3)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Breast Feeding
MH  - Chi-Square Distribution
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Eczema/epidemiology/immunology/*prevention & control
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Female
MH  - Food Hypersensitivity/epidemiology/immunology/*prevention & control
MH  - Humans
MH  - *Immunity, Maternally-Acquired
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Lactation/immunology
MH  - Logistic Models
MH  - Maternal Nutritional Physiological Phenomena
MH  - Pregnancy
MH  - Prevalence
MH  - Risk Factors
MH  - Skin Tests
EDAT- 2009/06/06 09:00
MHDA- 2009/10/21 06:00
CRDT- 2009/06/04 09:00
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2009/10/21 06:00 [medline]
AID - APA1355 [pii]
AID - 10.1111/j.1651-2227.2009.01355.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2009 Sep;98(9):1461-7. doi: 10.1111/j.1651-2227.2009.01355.x. Epub 
      2009 Jun 1.