PMID- 19490175
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20090720
IS  - 1468-1293 (Electronic)
IS  - 1464-2662 (Linking)
VI  - 10
IP  - 7
DP  - 2009 Aug
TI  - Later onset of herpes zoster-associated immune reconstitution inflammatory 
      syndrome.
PG  - 454-7
LID - 10.1111/j.1468-1293.2009.00700.x [doi]
AB  - OBJECTIVES: The aim of the study was to determine whether immune reconstitution 
      inflammatory syndrome (IRIS) associated with herpes zoster occurs on a different 
      time frame from other instances of IRIS. METHODS: Statistical analysis of onset 
      times of herpes zoster-associated IRIS and other cases of IRIS was carried out in 
      a retrospective cohort starting antiretroviral therapy at advanced stages of HIV 
      infection. RESULTS: Herpes zoster-associated IRIS was significantly more frequent 
      after the first 3 months of successful highly active antiretroviral therapy 
      (HAART), than other instances of IRIS (IRIS associated with tuberculosis, 
      Mycobacterium avium complex, Kaposi's sarcoma, etc.) which mainly occurred during 
      the first 3 months of treatment. CONCLUSIONS: The characteristic onset time 
      pattern of herpes zoster-associated IRIS, coincident with the second phase of 
      immune recovery under HAART, suggests that the immune recovery events underlying 
      herpes zoster-associated IRIS are different from those underlying other types of 
      IRIS. Our findings may be useful in improving the follow-up of individuals who 
      start HAART at an advanced stage of HIV infection.
FAU - Espinosa, E
AU  - Espinosa E
AD  - Centre for Infectious Diseases Research, Instituto Nacional de Enfermedades 
      Respiratorias Ismael Cosio Villegas, Mexico City 4502, 14080 Mexico. 
      reyesteran@cieni.org.mx
FAU - Pena-Jimenez, A
AU  - Pena-Jimenez A
FAU - Ormsby, C E
AU  - Ormsby CE
FAU - Vega-Barrientos, R
AU  - Vega-Barrientos R
FAU - Reyes-Teran, G
AU  - Reyes-Teran G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090326
PL  - England
TA  - HIV Med
JT  - HIV medicine
JID - 100897392
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-HIV Agents/*therapeutic use
MH  - *Antiretroviral Therapy, Highly Active
MH  - CD4 Lymphocyte Count
MH  - HIV Infections/complications/*drug therapy/immunology
MH  - Herpes Zoster/*immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*immunology
MH  - Retrospective Studies
MH  - Time Factors
MH  - Young Adult
EDAT- 2009/06/06 09:00
MHDA- 2010/07/21 06:00
CRDT- 2009/06/04 09:00
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
AID - HIV700 [pii]
AID - 10.1111/j.1468-1293.2009.00700.x [doi]
PST - ppublish
SO  - HIV Med. 2009 Aug;10(7):454-7. doi: 10.1111/j.1468-1293.2009.00700.x. Epub 2009 
      Mar 26.