PMID- 19490209
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20090603
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 36
IP  - 3
DP  - 2009 Jun
TI  - QTL for traits related to humoral immune response estimated from data of a 
      porcine F2 resource population.
PG  - 141-51
LID - 10.1111/j.1744-313X.2009.00838.x [doi]
AB  - This study aimed to map quantitative trait loci (QTL) for traits related to 
      humoral innate immune defence. Therefore, haemolytic complement activity in the 
      alternative and the classical pathway, serum concentration of C3c and of 
      haptoglobin (HP) were measured in blood samples obtained from F2 piglets (n = 
      457) of a porcine F2 resource population before and after Mycoplasma 
      hyopneumoniae, Aujeszky's disease virus (Suid herpesvirus I, SuHVI) and porcine 
      reproductive and respiratory syndrome virus (PRRSV) vaccination at 6, 14 and 16 
      weeks of age. Animals were genotyped at 88 autosomal markers. QTL analysis was 
      performed under the line cross and the half sib. Phenotypic data were adjusted 
      for systematic effects by mixed models with and without repeated measures 
      statement. In total, 46 and 21 estimated QTL positions were detected with 
      genome-wide significance at the 0.05 and 0.01 level, respectively. The proximal 
      region of SSC2 (orthologous to HSA11 0-70 Mb), the distal region of SSC4 (HSA1 
      95-155 Mb), and the intermediate region of SSC16 (HSA5 0-73 Mb and 150-174 Mb) 
      showed a clustering of estimated QTL positions for complement activity based on 
      the different models. A common genetic background, i.e. a single true QTL, might 
      underlie these QTL positions for related traits. In addition, QTL for antibody 
      titres were detected on SSC1, 2, 6 and 7. With regard to number and magnitude of 
      their impact, QTL for humoral innate immune traits behave like those for other 
      quantitative traits. Discovery of such QTL facilitates the identification of 
      candidate genes for disease resistance and immune competence that are applicable 
      in selective breeding and further research towards improving therapeutic and 
      prophylactic measures.
FAU - Wimmers, K
AU  - Wimmers K
AD  - Research Institute for the Biology of Farm Animals (FBN), Research Unit 
      'Molecular Biology', Dummerstorf, Germany. wimmers@fbn-dummerstorf.de
FAU - Murani, E
AU  - Murani E
FAU - Schellander, K
AU  - Schellander K
FAU - Ponsuksili, S
AU  - Ponsuksili S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (Antibodies)
RN  - 0 (Haptoglobins)
RN  - 80295-44-9 (Complement C3c)
SB  - IM
MH  - Animals
MH  - Antibodies/blood
MH  - Antibody Formation/*genetics
MH  - Chromosome Mapping
MH  - Complement C3c/analysis
MH  - Haptoglobins/analysis
MH  - Herpesvirus 1, Suid/immunology
MH  - Immunity, Innate/*genetics
MH  - Mycoplasma hyopneumoniae/immunology
MH  - Porcine respiratory and reproductive syndrome virus/immunology
MH  - Quantitative Trait Loci/*genetics
MH  - Swine/*genetics/*immunology
MH  - *Vaccination
EDAT- 2009/06/06 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/06/04 09:00
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - EJI838 [pii]
AID - 10.1111/j.1744-313X.2009.00838.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2009 Jun;36(3):141-51. doi: 10.1111/j.1744-313X.2009.00838.x.