PMID- 19491012
OWN - NLM
STAT- MEDLINE
DCOM- 20090824
LR  - 20131121
IS  - 1879-0720 (Electronic)
IS  - 0928-0987 (Linking)
VI  - 37
IP  - 3-4
DP  - 2009 Jun 28
TI  - Tailoring vancomycin release from beta-TCP/agarose scaffolds.
PG  - 249-56
LID - 10.1016/j.ejps.2009.02.011 [doi]
AB  - In this work a multifaceted approach to the fabrication of scaffolds is 
      considered, that is, besides the preparation technique, the introduction of 
      substances that may contribute to enhance their final performance, as well as the 
      techniques required to ensure the correct preservation of the so obtained 
      scaffolds are taken into account to tailor the release of vancomycin from 
      beta-tricalcium phosphate (beta-TCP)/agarose scaffolds. These materials were 
      prepared by a shaping technique that allows to obtain pieces at a temperature low 
      enough to simultaneously include active substances susceptible of heat degrading 
      such as vancomycin, the model drug considered in this work. In the first 
      approximation poly(ethylene glycol) (PEG), a hydrophilic substance employed as a 
      matrix capable of binding compounds such as proteins or peptides and release them 
      in a controlled fashion, was included in the formulation. The second tool to 
      govern the vancomycin liberation is based on the drying procedures employed to 
      process and preserve the obtained scaffolds: freeze-drying and heat desiccation 
      at 37 degrees C. These modifications resulted in the generation of different pore 
      architectures and certain chemical interactions, such as the formation of an 
      agarose-PEG-vancomycin complex that yielded different drug release patterns. The 
      so obtained pieces behave like a hydrogel when immersed in a hydrated medium but 
      show a consistency comparable to that of the cancellous bone.
FAU - Cabanas, M V
AU  - Cabanas MV
AD  - Departamento de Quimica Inorganica y Bioinorganica, Facultad de Farmacia, 
      Universidad Complutense de Madrid, 28040 Madrid, Spain.
FAU - Pena, J
AU  - Pena J
FAU - Roman, J
AU  - Roman J
FAU - Vallet-Regi, M
AU  - Vallet-Regi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090305
PL  - Netherlands
TA  - Eur J Pharm Sci
JT  - European journal of pharmaceutical sciences : official journal of the European 
      Federation for Pharmaceutical Sciences
JID - 9317982
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 6Q205EH1VU (Vancomycin)
RN  - 9012-36-6 (Sepharose)
RN  - K4C08XP666 (tricalcium phosphate)
SB  - IM
MH  - Anti-Bacterial Agents/*administration & dosage/chemistry
MH  - Calcium Phosphates/*chemistry
MH  - Chemistry, Pharmaceutical
MH  - Delayed-Action Preparations
MH  - Desiccation
MH  - *Drug Carriers
MH  - Drug Compounding
MH  - Freeze Drying
MH  - Microscopy, Electron, Scanning
MH  - Porosity
MH  - Sepharose/*chemistry
MH  - Solubility
MH  - Temperature
MH  - Vancomycin/*administration & dosage/chemistry
MH  - X-Ray Diffraction
EDAT- 2009/06/06 09:00
MHDA- 2009/08/25 09:00
CRDT- 2009/06/04 09:00
PHST- 2008/11/11 00:00 [received]
PHST- 2009/01/19 00:00 [revised]
PHST- 2009/02/18 00:00 [accepted]
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2009/08/25 09:00 [medline]
AID - S0928-0987(09)00064-5 [pii]
AID - 10.1016/j.ejps.2009.02.011 [doi]
PST - ppublish
SO  - Eur J Pharm Sci. 2009 Jun 28;37(3-4):249-56. doi: 10.1016/j.ejps.2009.02.011. 
      Epub 2009 Mar 5.