PMID- 19491073
OWN - NLM
STAT- MEDLINE
DCOM- 20100128
LR  - 20211203
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 15
IP  - 6
DP  - 2009 Sep-Oct
TI  - Parathyroid carcinoma in multiple endocrine neoplasia type 1 with a classic 
      germline mutation.
PG  - 567-72
LID - 10.4158/EP09045.CRR1 [doi]
AB  - OBJECTIVE: To report the case of a patient with multiple endocrine neoplasia type 
      1 (MEN 1) syndrome with con-comitant parathyroid carcinoma and a classic MEN1 
      germline mutation. METHODS: We present the clinical findings, laboratory results, 
      imaging studies, and surgical histopathologic features in a woman with MEN 1 
      syndrome and concomitant parathyroid carcinoma. We also review the literature 
      regarding patients with similar clinical entities and the use of adjuvant 
      radiotherapy for parathyroid carcinoma. RESULTS: A 53-year-old woman presented 
      with nausea and severe primary hyperparathyroidism. Computed tomography revealed 
      parathyroid masses, shown later to be bilateral parathyroid carcinomas and 
      adenomas. Magnetic resonance imaging demonstrated a pituitary macroadenoma, and 
      gastrinomas were confirmed by computed tomography and a secretin stimulation 
      test. She was successfully treated with total thyroidectomy, subtotal 
      parathyroidectomy, and adjuvant radiotherapy. Genetic analysis revealed a classic 
      MEN1 germline mutation. CONCLUSION: This report describes a patient with 
      parathyroid carcinoma occurring in conjunction with MEN 1, further characterizing 
      this rare condition. In contrast to previously described patients, our patient is 
      the first with a classic MEN1 germline mutation, confirming that parathyroid 
      cancer can occur in association with classic MEN 1 genetics.
FAU - Shih, Roger Y W
AU  - Shih RY
AD  - Department of Internal Medicine, United States Air Force Medical Service, Wilford 
      Hall Medical Center, San Antonio, Texas, USA. Roger.Shih3@lackland.af.mil
FAU - Fackler, Sarah
AU  - Fackler S
FAU - Maturo, Stephen
AU  - Maturo S
FAU - True, Mark W
AU  - True MW
FAU - Brennan, Joseph
AU  - Brennan J
FAU - Wells, David
AU  - Wells D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
SB  - IM
MH  - *Adenocarcinoma/genetics/surgery/therapy
MH  - Female
MH  - *Gastrinoma/genetics/therapy
MH  - *Germ-Line Mutation
MH  - Hispanic or Latino
MH  - Humans
MH  - Hyperparathyroidism, Primary/etiology
MH  - Middle Aged
MH  - *Multiple Endocrine Neoplasia Type 1/genetics/surgery/therapy
MH  - *Parathyroid Neoplasms/genetics/surgery/therapy
MH  - Parathyroidectomy
MH  - Radiotherapy, Adjuvant
MH  - Thyroidectomy
EDAT- 2009/06/06 09:00
MHDA- 2010/01/29 06:00
CRDT- 2009/06/04 09:00
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2010/01/29 06:00 [medline]
AID - S1530-891X(20)41366-7 [pii]
AID - 10.4158/EP09045.CRR1 [doi]
PST - ppublish
SO  - Endocr Pract. 2009 Sep-Oct;15(6):567-72. doi: 10.4158/EP09045.CRR1.