PMID- 19491075
OWN - NLM
STAT- MEDLINE
DCOM- 20100226
LR  - 20210204
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 15
IP  - 7
DP  - 2009 Nov-Dec
TI  - Zollinger-Ellison syndrome due to primary gastrinoma of the extrahepatic biliary 
      tree: three case reports and review of literature.
PG  - 737-49
LID - 10.4158/EP09022.RAR [doi]
AB  - OBJECTIVE: To report 3 cases of primary neuroendocrine tumors (PNT) of the 
      extrahepatic biliary tree (EHBT) in patients with Zollinger-Ellison syndrome 
      (ZES), 2 of whom had multiple endocrine neoplasia type 1 (MEN 1). METHODS: Three 
      new cases of gastrin-producing tumors of the EHBT are presented, and the 
      pertinent literature relating to PNT of the EHBT is reviewed. RESULTS: Eighty-one 
      previous cases of PNT of the EHBT have been reported in the world literature, 7 
      of which were hormonally active and associated with peptic ulcer disease, 
      diarrhea, or ZES. Three additional patients presented to us with ZES due to PNT 
      of the EHBT. One patient with MEN 1 was treated with a Whipple procedure for a 
      common bile duct gastrinoma. A second patient underwent left hepatectomy with 
      resection of the confluence of the right and left hepatic ducts for a primary 
      left hepatic duct gastrinoma. The second patient with MEN 1 under-went resection 
      of a gastrinoma at the junction of the cystic duct and the common bile duct. 
      CONCLUSION: Although PNT of the EHBT are uncommon, the association with ZES is 
      even more so. Often, nonfunctioning tumors are diagnosed late in the course of 
      the disease from symptoms related to biliary obstruction. Patients with ZES may 
      be diagnosed earlier because of symptoms resulting from gastrin excess. Surgical 
      resection is the only chance for cure and is often helpful in the palliation of 
      symptoms.
FAU - Price, Theolyn N
AU  - Price TN
AD  - Department of Surgery, Mayo Clinic Rochester and Mayo Foundation, Rochester, 
      Minnesota 55905, USA.
FAU - Thompson, Geoffrey B
AU  - Thompson GB
FAU - Lewis, Jason T
AU  - Lewis JT
FAU - Lloyd, Ricardo V
AU  - Lloyd RV
FAU - Young, William F
AU  - Young WF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
SB  - IM
MH  - Adult
MH  - Bile Ducts, Extrahepatic/*pathology
MH  - Fatal Outcome
MH  - Female
MH  - Gastrinoma/*complications/pathology/surgery/therapy
MH  - Humans
MH  - Middle Aged
MH  - Neuroendocrine Tumors/*complications/pathology/surgery/therapy
MH  - Pregnancy
MH  - Zollinger-Ellison Syndrome/*diagnosis/*etiology/surgery/therapy
RF  - 107
EDAT- 2009/06/06 09:00
MHDA- 2010/02/27 06:00
CRDT- 2009/06/04 09:00
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2010/02/27 06:00 [medline]
AID - S1530-891X(20)41555-1 [pii]
AID - 10.4158/EP09022.RAR [doi]
PST - ppublish
SO  - Endocr Pract. 2009 Nov-Dec;15(7):737-49. doi: 10.4158/EP09022.RAR.