PMID- 19492245
OWN - NLM
STAT- MEDLINE
DCOM- 20100316
LR  - 20091120
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 44
IP  - 8
DP  - 2009
TI  - Down-regulation of HLA class I antigen-processing machinery components in 
      esophageal squamous cell carcinomas: association with disease progression.
PG  - 960-9
LID - 10.1080/00365520902998679 [doi]
AB  - OBJECTIVE: Lack of human leukocyte antigen (HLA) presentation has been proposed 
      to contribute to the immune evasion of cancer cells in some cancers including 
      esophageal cancer. The aim of this study was to examine the expression of HLA 
      class I antigen and the antigen-processing machinery (APM) components in 
      esophageal squamous cell carcinoma (ESCC) lesions and to assess their association 
      with histopathological characteristics. MATERIAL AND METHODS: A total of 143 
      formalin-fixed, paraffin-embedded ESCC lesions collected in two hospitals in 
      Shandong Province of China were studied. The expression levels were determined by 
      immunohistochemistry. RESULTS: TAP1, TAP2, LMP2, LMP7, beta2m, and HLA class I 
      antigen were lost or down-regulated in 30.8%, 35.0%, 45.0%, 48.0%, 56.0%, and 
      60.8% of the ESCC lesions tested, respectively. The loss of or down-regulated 
      expressions of HLA class I, beta2m, TAP1, LMP2, and LMP7 in tumor lesions were 
      all significantly correlated to tumor grade and lymph node status. Expression of 
      HLA class I antigens was strongly correlated to the expression levels of beta2m, 
      TAP1, TAP2, LMP2, and LMP7, suggesting APM component defects as a mechanism 
      underlying HLA class I antigen down-regulation in ESCC lesions. Expression of APM 
      components and HLA class I antigens was significantly associated with the extent 
      of intratumoral T-cell infiltration. CONCLUSIONS: Our results indicate that lack 
      or reduction of HLA class I antigens and expression of APM components in ESCC may 
      render some tumor cells to escape the immunosurveillance mediated by CD8(+) T 
      cells and contribute to the clinical course of ESCC.
FAU - Liu, Qiao
AU  - Liu Q
AD  - Department of Cellular and Molecular Biology, Cancer Institute & Hospital, Peking 
      Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. 
      liuqiao80@gmail.com
FAU - Hao, Chunyan
AU  - Hao C
FAU - Su, Peng
AU  - Su P
FAU - Shi, Juanhong
AU  - Shi J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
SB  - IM
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Carcinoma, Squamous Cell/*immunology/pathology
MH  - China
MH  - Disease Progression
MH  - *Down-Regulation
MH  - Esophageal Neoplasms/*immunology/pathology
MH  - Female
MH  - Genes, MHC Class I/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2009/06/06 09:00
MHDA- 2010/03/17 06:00
CRDT- 2009/06/04 09:00
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 911911637 [pii]
AID - 10.1080/00365520902998679 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2009;44(8):960-9. doi: 10.1080/00365520902998679.