PMID- 19493233
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 6
DP  - 2009 Jun
TI  - Distribution of HLA-A, -B, -Cw, and -DRB1 alleles and haplotypes in an isolated 
      Han population in Southwest China.
PG  - 561-8
LID - 10.1111/j.1399-0039.2009.01237.x [doi]
AB  - In this study, polymorphisms of human leukocyte antigen (HLA) class I (A, B, and 
      Cw) and class II (DRB1) loci were analyzed in an isolated Han population living 
      in Fengyandong in the Yunnan province of Southwest China (FYDH) using a 
      high-resolution polymerase chain reaction-Luminex typing method. A total of 13 A, 
      26 B, 15 Cw, and 23 DRB1 alleles of HLA were found in FYDH. The frequencies of 
      A*1101, A*0207, A*2402, B*4601, B*1502, Cw*0102, Cw*0801, DRB1*0901, and 
      DRB1*1202 were >10%. The following haplotypes were common with frequencies >5%: 
      three A-B, four Cw-B, two B-DRB1, two A-B-DRB1, three A-B-Cw, two B-Cw-DRB1, and 
      two A-B-Cw-DRB1 phylogenetic tree and multidimensional scaling analysis based on 
      HLA-A, -B, and -DRB1 allele frequencies of 18 Han populations suggested that FYDH 
      was an isolated Han population, but the analytic result also provided a 
      suggestion that FYDH was genetically related to Chinese Southern Han. According 
      to the characteristics of the HLA allele and haplotype distributions and 
      significantly reduced allelic and haplotypic diversity in FYDH, we deduced that 
      genetic drift and/or selection and subsequent geographic isolation had influenced 
      the distribution characteristics of the HLA gene in FYDH. In addition, 
      significantly reduced allelic and haplotypic diversity in FYDH makes it an ideal 
      homogenous population and very useful model for future investigations of issues 
      related to immunogenetic diseases in the Han population.
FAU - Yao, Y
AU  - Yao Y
AD  - Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Kunming, China.
FAU - Shi, L
AU  - Shi L
FAU - Shi, L
AU  - Shi L
FAU - Matsushita, M
AU  - Matsushita M
FAU - Yu, L
AU  - Yu L
FAU - Lin, K
AU  - Lin K
FAU - Tao, Y
AU  - Tao Y
FAU - Huang, X
AU  - Huang X
FAU - Yi, W
AU  - Yi W
FAU - Oka, T
AU  - Oka T
FAU - Tokunaga, K
AU  - Tokunaga K
FAU - Chu, J
AU  - Chu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*12:02 antigen)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Genetic Variation
MH  - Genetics, Population
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Phylogeny
EDAT- 2009/06/06 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/06/05 09:00
PHST- 2009/06/05 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - TAN1237 [pii]
AID - 10.1111/j.1399-0039.2009.01237.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jun;73(6):561-8. doi: 10.1111/j.1399-0039.2009.01237.x.