PMID- 19493234
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20220316
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 6
DP  - 2009 Jun
TI  - HLA-B is the best candidate of susceptibility genes in HLA for Japanese 
      ulcerative colitis.
PG  - 569-74
LID - 10.1111/j.1399-0039.2009.01241.x [doi]
AB  - Recently, a genome-wide association study for ulcerative colitis (UC) in the UK 
      population was reported, and several susceptibility loci including the human 
      leukocyte antigen (HLA) region were identified. The strongest association in the 
      HLA region was found at a 400 kb haplotype block containing HLA-DRB1. In Japanese 
      population, previous study suggested the association between UC and HLA-B*52; 
      however, HLA typing was determined using serotyping with the small sample size. 
      The purpose of this study was to perform an association study in HLA-B by 
      genotyping. A total of 320 patients with UC and 322 healthy controls were 
      recruited in this case-control study. All subjects were Japanese. Genotyping of 
      HLA-B was performed by polymerase chain reaction using a sequence-specific 
      primer. When the allele frequencies were compared, significant associations were 
      found with B*52 [odds ratio (OR) = 3.65, P = 1.6 x 10(-17), P(c) = 3.7 x 10(-16)] 
      and B*4002 (OR = 0.52, P = 0.00030, P(c) = 0.0068). The allele frequency of B*52 
      was significantly higher in patients diagnosed before 40 years of age than in 
      those diagnosed after 40 years (OR = 1.79, P = 0.010, P(c) = 0.020). A 
      combination association map of Japanese UC using our current and previous studies 
      showed two equal peaks of association on HLA-DRB1 and HLA-B, indicating the 
      possible existence of two casual variants in the HLA region inside and outside 
      the 400 kb block found in UK. We conclude that HLA-B contributes to the 
      susceptibility to Japanese UC, especially cases with younger age of onset. The 
      strength of association for HLA-B was equal to that for HLA-DRB1 in Japanese UC, 
      in contrast to the UK population.
FAU - Aizawa, H
AU  - Aizawa H
AD  - Division of Gastroenterology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Kinouchi, Y
AU  - Kinouchi Y
FAU - Negoro, K
AU  - Negoro K
FAU - Nomura, E
AU  - Nomura E
FAU - Imai, G
AU  - Imai G
FAU - Takahashi, S
AU  - Takahashi S
FAU - Takagi, S
AU  - Takagi S
FAU - Kakuta, Y
AU  - Kakuta Y
FAU - Tosa, M
AU  - Tosa M
FAU - Mochida, A
AU  - Mochida A
FAU - Matsumura, Y
AU  - Matsumura Y
FAU - Endo, K
AU  - Endo K
FAU - Shimosegawa, T
AU  - Shimosegawa T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Colitis, Ulcerative/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Young Adult
EDAT- 2009/06/06 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/06/05 09:00
PHST- 2009/06/05 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - TAN1241 [pii]
AID - 10.1111/j.1399-0039.2009.01241.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jun;73(6):569-74. doi: 10.1111/j.1399-0039.2009.01241.x.