PMID- 19493393
OWN - NLM
STAT- MEDLINE
DCOM- 20091006
LR  - 20131121
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 122
IP  - 7
DP  - 2009 Apr 5
TI  - Prognostic factors affecting the all-cause death and sudden cardiac death rates 
      of post myocardial infarction patients with low left ventricular ejection 
      fraction.
PG  - 802-6
AB  - BACKGROUND: Post myocardial infarction (post-MI) patients with low left 
      ventricular ejection fraction (LVEF) have been candidates for an implantable 
      cardioverter-defibrillator (ICD) since the Multicenter Automatic Defibrillator 
      Implantation Trail II (MADIT II). However, due to the high costs of ICDs, 
      widespread usage has not been accepted. Therefore, further risk stratification 
      for post-MI patients with low LVEF may aid in the selection of patients that will 
      benefit most from ICD treatment. METHODS: Four hundred and seventeen post-MI 
      patients with low LVEF (< or = 35%) were enrolled in the study. All the patients 
      received standard examination and proper treatment and were followed up to 
      observe the all-cause death rate and sudden cardiac death (SCD) rate. Then COX 
      proportional-hazards regression model was used to investigate the clinical 
      factors which affect the all-cause death rate and SCD rate. RESULTS: Of 55 
      patients who died during (32 +/- 24) months of follow-up, 37 (67%) died suddenly. 
      After adjusting for baseline clinical characteristics, multivariate COX 
      proportional-hazards regression model identified the following variables 
      associated with death from all causes: New York Heart Association (NYHA) heart 
      failure class > or = III (Hazard ratio: 2.361), LVEF < or = 20% (Hazard ratio: 
      2.514), sustained ventricular tachycardia (Hazard ratio: 6.453), and age > or = 
      70 years (Hazard ratio: 3.116). The presence of sustained ventricular tachycardia 
      (Hazard ratio: 6.491) and age > or = 70 years (Hazard ratio: 2.694) were 
      specifically associated with SCD. CONCLUSIONS: In the post-MI patients with low 
      LVEF, factors as LVEF < or = 20%, age > or = 70 years, presence of ventricular 
      tachycardia, and NYHA heart failure class > or = III predict an adverse outcome. 
      The presence of sustained ventricular tachycardia and age > or = 70 years was 
      associated with occurrence of SCD in these patients.
FAU - Dai, Shi-Mo
AU  - Dai SM
AD  - Center for Arrhythmia Diagnosis and Treatment, Fu Wai Hospital and Cardiovascular 
      Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      Beijing 100037, China.
FAU - Zhang, Shu
AU  - Zhang S
FAU - Chen, Ke-Ping
AU  - Chen KP
FAU - Hua, Wei
AU  - Hua W
FAU - Wang, Fang-Zheng
AU  - Wang FZ
FAU - Chen, Xin
AU  - Chen X
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Anti-Arrhythmia Agents)
RN  - N3RQ532IUT (Amiodarone)
SB  - IM
MH  - Aged
MH  - Amiodarone/therapeutic use
MH  - Angioplasty, Balloon
MH  - Angiotensin-Converting Enzyme Inhibitors/therapeutic use
MH  - Anti-Arrhythmia Agents/therapeutic use
MH  - Cause of Death
MH  - Coronary Artery Bypass
MH  - *Death, Sudden, Cardiac
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/drug therapy/*mortality/surgery/therapy
MH  - Proportional Hazards Models
MH  - Ventricular Dysfunction, Left/drug therapy/mortality/surgery/therapy
EDAT- 2009/06/06 09:00
MHDA- 2009/10/07 06:00
CRDT- 2009/06/05 09:00
PHST- 2009/06/05 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2009/10/07 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2009 Apr 5;122(7):802-6.