PMID- 19494392
OWN - NLM
STAT- MEDLINE
DCOM- 20090814
LR  - 20161020
IS  - 1024-2708 (Print)
IS  - 1024-2708 (Linking)
VI  - 15
IP  - 3 Suppl 3
DP  - 2009 Jun
TI  - Unrelated donor haematopoietic stem cell transplantation for adult patients with 
      haematological malignancies.
PG  - 22-6
AB  - Unrelated donor (URD) is an acceptable source of stem cell grafts for adults. 
      With the growth in available URD, improved human leukocyte antigen (HLA) typing 
      technology and better understanding of HLA matching, the number of URD 
      haematopoietic stem cell transplantation (URD-HSCT) is increasing dramatically in 
      recent years. Peripheral blood stem cells have surpassed bone marrow as the 
      preferred stem cell source for URD-HSCT, and more unrelated cord blood 
      transplantations have been successfully performed in adults. Majority of URD 
      transplants are for haematological malignancies, and acute leukaemia has become 
      the most common disease, while the percentage of older patients receiving URD 
      transplants is increasing. Clinical advances in URD-HSCT have greatly improved 
      the outcomes, which are now comparable to related donor HSCT, however, 
      transplant-related mortality (TRM) remains the most considerable problem in 
      URD-HSCT. It is worth noting that non-myeloablative or reduced-intensity 
      conditioning regimens have been introduced and utilised increasingly in URD-HSCT 
      recently, which reduce the TRM and expand eligible patients for URD-HSCT. Since 
      the family size is decreasing in China, URD represents the most common 
      alternative source of stem cell for HSCT. However, further improvements are 
      necessary in the setting of URD-HSCT.
FAU - Huang, H
AU  - Huang H
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang 
      University School of Medicine. hehuang.zju@gmail.com
FAU - Lai, X Y
AU  - Lai XY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Hong Kong Med J
JT  - Hong Kong medical journal = Xianggang yi xue za zhi
JID - 9512509
SB  - IM
MH  - Adult
MH  - Hematologic Neoplasms/*therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Transplantation Conditioning
MH  - Transplantation, Homologous
EDAT- 2009/06/25 09:00
MHDA- 2009/08/15 09:00
CRDT- 2009/06/05 09:00
PHST- 2009/06/05 09:00 [entrez]
PHST- 2009/06/25 09:00 [pubmed]
PHST- 2009/08/15 09:00 [medline]
PST - ppublish
SO  - Hong Kong Med J. 2009 Jun;15(3 Suppl 3):22-6.