PMID- 19494474
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20221207
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
VI  - 121
IP  - 3 Suppl 1
DP  - 2009 May
TI  - The role of colesevelam HCl in type 2 diabetes mellitus therapy.
PG  - 19-24
LID - 10.3810/pgm.2009.05.suppl53.289 [doi]
AB  - Colesevelam hydrochloride (HCl) was approved in January 2008 as an adjunct 
      therapy for improving glycemic control in patients with type 2 diabetes mellitus 
      (T2DM). Colesevelam HCl is a bile acid sequestrant that has been shown to 
      significantly improve both glycemic control and the lipid profile in patients 
      with T2DM when added to metformin-, sulfonylurea-, or insulin-based therapy. In 
      addition, colesevelam HCl may be useful for reducing glucose and low-density 
      lipoprotein cholesterol levels in patients with prediabetes (defined as fasting 
      plasma glucose levels of 100-125 mg/dL or 2-hour poststimulation glucose levels 
      of 140-199 mg/dL), who have an increased cardiovascular risk. As colesevelam HCl 
      is a unique agent-with both significant glycemic and lipid benefits-it has the 
      potential to play an important role in the management of T2DM. This article 
      reviews the place of colesevelam HCl in therapy (both for T2DM and prediabetes), 
      the benefits of early, intensive treatment of T2DM, and the importance of safe 
      glycemic control later in the disease process.
FAU - Handelsman, Yehuda
AU  - Handelsman Y
AD  - Metabolic Institute of America, Tarzana, CA 91356, USA. yhandelsman@pacbell.net
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 48G762T011 (Allylamine)
RN  - P4SG24WI5Q (Colesevelam Hydrochloride)
SB  - IM
MH  - Allylamine/*analogs & derivatives/therapeutic use
MH  - Anticholesteremic Agents/*therapeutic use
MH  - Blood Glucose/drug effects
MH  - Cholesterol, LDL/drug effects
MH  - Colesevelam Hydrochloride
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Glycated Hemoglobin/drug effects
MH  - Humans
MH  - Hypercholesterolemia/*drug therapy
MH  - Life Style
MH  - Patient Education as Topic/*methods
MH  - Primary Prevention/methods
MH  - United States
RF  - 33
EDAT- 2009/06/13 09:00
MHDA- 2009/07/08 09:00
CRDT- 2009/06/05 09:00
PHST- 2009/06/05 09:00 [entrez]
PHST- 2009/06/13 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
AID - 10.3810/pgm.2009.05.suppl53.289 [doi]
PST - ppublish
SO  - Postgrad Med. 2009 May;121(3 Suppl 1):19-24. doi: 
      10.3810/pgm.2009.05.suppl53.289.