PMID- 19496998
OWN - NLM
STAT- MEDLINE
DCOM- 20091013
LR  - 20220409
IS  - 1440-1819 (Electronic)
IS  - 1323-1316 (Linking)
VI  - 63
IP  - 4
DP  - 2009 Aug
TI  - Autonomic nervous system activity and psychiatric severity in schizophrenia.
PG  - 538-45
LID - 10.1111/j.1440-1819.2009.01983.x [doi]
AB  - AIMS: Schizophrenia patients have a mortality rate two to three-fold higher than 
      that of the general population. Despite the disorder's widespread recognition, 
      how and to what extent autonomic nervous system (ANS) activity contributes to 
      schizophrenia remains inconclusive. The aim of the present study, therefore, was 
      to determine the extent of ANS activity depression with respect to healthy, 
      well-matched control subjects and the severity of psychiatric disorders as 
      determined using the Global Assessment of Functioning (GAF) scale among 
      schizophrenia patients with special reference to antipsychotic dose. METHODS: 
      This study included 71 schizophrenia patients and 72 healthy controls. ANS 
      activity was assessed by means of heart rate variability power spectral analysis. 
      RESULTS: ANS-related spectral parameters were three-four-fold lower in the 
      patients compared to the control group (P < 0.01). Furthermore, when the patients 
      without cardiovascular complications were classified according to GAF score, 
      overall ANS (P = 0.033) and parasympathetic nervous system (PNS) activity (P = 
      0.025) were significantly reduced in the low-GAF as compared to the high-GAF 
      group. Partial correlation analyses demonstrated that ANS activity was 
      significantly correlated with GAF score while statistically eliminating the 
      effects of age, gender, body mass index, antipsychotic dose, and lipid profiles 
      of the patient population. CONCLUSION: The significantly lower ANS activity in 
      the low-GAF group suggests that such autonomic functional depression could be 
      associated with the severity of schizophrenia. The present data further imply 
      that schizophrenia patients with more depressed overall ANS and PNS activity 
      might encounter increasing risks for cardiovascular events such as sudden death.
FAU - Fujibayashi, Mami
AU  - Fujibayashi M
AD  - Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 
      Japan.
FAU - Matsumoto, Tamaki
AU  - Matsumoto T
FAU - Kishida, Ikuko
AU  - Kishida I
FAU - Kimura, Tetsuya
AU  - Kimura T
FAU - Ishii, Chie
AU  - Ishii C
FAU - Ishii, Norio
AU  - Ishii N
FAU - Moritani, Toshio
AU  - Moritani T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090522
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Antipsychotic Agents/adverse effects/therapeutic use
MH  - Autonomic Nervous System/physiopathology
MH  - Autonomic Nervous System Diseases/*diagnosis/physiopathology
MH  - Death, Sudden, Cardiac/etiology
MH  - Electrocardiography/statistics & numerical data
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parasympathetic Nervous System/physiopathology
MH  - Psychiatric Status Rating Scales
MH  - Risk Factors
MH  - Schizophrenia/*diagnosis/drug therapy/*physiopathology
MH  - Severity of Illness Index
MH  - Sympathetic Nervous System/physiopathology
EDAT- 2009/06/06 09:00
MHDA- 2009/10/14 06:00
CRDT- 2009/06/06 09:00
PHST- 2009/06/06 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2009/10/14 06:00 [medline]
AID - PCN1983 [pii]
AID - 10.1111/j.1440-1819.2009.01983.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2009 Aug;63(4):538-45. doi: 
      10.1111/j.1440-1819.2009.01983.x. Epub 2009 May 22.