PMID- 19497038
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 74
IP  - 2
DP  - 2009 Aug
TI  - HLA-B*15 subtypes in Burmese population by sequence-based typing.
PG  - 164-7
LID - 10.1111/j.1399-0039.2009.01281.x [doi]
AB  - Human leukocyte antigen (HLA)-B*15 encompasses an increasing number of subtypes 
      of more than 150. Frequency studies and a strong genetic association between HLA 
      subtypes and susceptibility to drug hypersensitivity have been reported in 
      different ethnic populations. To identify HLA-B*15 subtypes in Burmese using 
      sequence-based typing (SBT) method, we selected 65 HLA-B*15-positive samples from 
      170 unrelated healthy Burmese who were genotyped HLA-B* by polymerase chain 
      reaction with the sequence-specific primer method. The frequency of HLA-B*15 in 
      Burmese was found to be 38.2%. By the SBT method, results showed 10 alleles of 
      HLA-B*15 subtypes. Four common alleles, B*1502 (45.2%), B*1532 (16.4%), B*1525 
      (12.3%), and B*1501 (8.2%), were found in 82.1% of HLA-B*15-positive Burmese. 
      Whereas the B*1501 was the highest in the Caucasians, Koreans, and Japanese, the 
      highest frequency of HLA-B*15 alleles in Burmese was B*1502 (45.2%) that is 
      similar to the frequency found in northeastern Thais and Vietnamese. This study 
      is the first report of HLA-B*15 subtypes in Burmese. These results will provide 
      the basic data in the further study in transplantations, genetic association with 
      diseases, and drug hypersensitivity.
FAU - Kongmaroeng, C
AU  - Kongmaroeng C
AD  - PhD Program in Biomedical Science, Faculty of Graduate School, Khon Kaen 
      University, Khon Kaen, Thailand. arunrant@kku.ac.th
FAU - Romphruk, A
AU  - Romphruk A
FAU - Ruangwerayut, R
AU  - Ruangwerayut R
FAU - Paupairoj, C
AU  - Paupairoj C
FAU - Leelayuwat, C
AU  - Leelayuwat C
FAU - Inoko, H
AU  - Inoko H
FAU - Romphruk, A
AU  - Romphruk A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090602
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B15 Antigen)
SB  - IM
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-B Antigens/analysis/classification/*genetics
MH  - HLA-B15 Antigen
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Myanmar/ethnology
MH  - Polymorphism, Genetic
MH  - Sequence Analysis, DNA
MH  - Thailand
EDAT- 2009/06/06 09:00
MHDA- 2009/10/09 06:00
CRDT- 2009/06/06 09:00
PHST- 2009/06/06 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
AID - TAN1281 [pii]
AID - 10.1111/j.1399-0039.2009.01281.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Aug;74(2):164-7. doi: 10.1111/j.1399-0039.2009.01281.x. 
      Epub 2009 Jun 2.