PMID- 19498079
OWN - NLM
STAT- MEDLINE
DA  - 20090630
DCOM- 20090916
LR  - 20091118
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Linking)
VI  - 37
IP  - Web Server issue
DP  - 2009 Jul 1
TI  - Gendoo: functional profiling of gene and disease features using MeSH
      vocabulary.
PG  - W166-9
AB  - Genome-wide data enables us to clarify the underlying molecular mechanisms
      of complex phenotypes. The Online Mendelian Inheritance in Man (OMIM) is a
      widely employed knowledge base of human genes and genetic disorders for
      biological researchers. However, OMIM has not been fully exploited for
      omics analysis because its bibliographic data structure is not suitable
      for computer automation. Here, we characterized diseases and genes by
      generating feature profiles of associated drugs, biological phenomena and
      anatomy with the MeSH (Medical Subject Headings) vocabulary. We obtained 1
      760 054 pairs of OMIM entries and MeSH terms by utilizing the full set of
      MEDLINE articles. We developed a web-based application called Gendoo
      (gene, disease features ontology-based overview system) to visualize these
      profiles. By comparing feature profiles of types 1 and 2 diabetes, we
      clearly illustrated their differences: type 1 diabetes is an autoimmune
      disease (P-value = 4.55 x 10(-5)) and type 2 diabetes is related to
      obesity (P-value = 1.18 x 10(-15)). Gendoo and the developed feature
      profiles should be useful for omics analysis from molecular and clinical
      viewpoints. Gendoo is available at http://gendoo.dbcls.jp/.
AD  - Database Center for Life Science, Research Organization of Information and
      Systems, Faculty of Engineering Building 12, The University of Tokyo,
      2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. nakazato@dbcls.rois.ac.jp
FAU - Nakazato, Takeru
AU  - Nakazato T
FAU - Bono, Hidemasa
AU  - Bono H
FAU - Matsuda, Hideo
AU  - Matsuda H
FAU - Takagi, Toshihisa
AU  - Takagi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090604
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
SB  - IM
MH  - *Databases, Genetic
MH  - Diabetes Mellitus/classification
MH  - Disease/*genetics
MH  - Genes
MH  - Internet
MH  - *Medical Subject Headings
MH  - *Software
PMC - PMC2703956
OID - NLM: PMC2703956
EDAT- 2009/06/06 09:00
MHDA- 2009/09/17 06:00
CRDT- 2009/06/06 09:00
PHST- 2009/06/04 [aheadofprint]
AID - gkp483 [pii]
AID - 10.1093/nar/gkp483 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2009 Jul 1;37(Web Server issue):W166-9. Epub 2009 Jun
      4.