PMID- 19499712
OWN - NLM
STAT- MEDLINE
DCOM- 20090717
LR  - 20161020
IS  - 0235-2990 (Print)
IS  - 0235-2990 (Linking)
VI  - 54
IP  - 1-2
DP  - 2009
TI  - [Inhibitory effect of foscarnet and acyclovir on reproduction of human 
      herpesvirus 6 in cell culture].
PG  - 17-9
AB  - Two practically important antiviral agents, i.e. foscarnet (phosphonoformic acid, 
      foscavir) and acyclovir, and their inhibitory effect on reproduction of human 
      herpesvirus 6 (HHV-6) were investigated in an experiment with sensitive 
      lymphoblastoic cell line HSB-2. Phosphonoformic acid (PFA) was shown advantageous 
      vs. acyclovir. In a model of HHV-6 infection acyclovir was low active 
      (chemotherapeutic index of 0.9) and its use in clinical practice is not useful, 
      whereas PFA (chemoterapeutic index of 10) and similar agents showed significant 
      antiviral activity that indicated the necessity of their further investigation.
FAU - Mel'nichenko, A V
AU  - Mel'nichenko AV
FAU - L'vov, N D
AU  - L'vov ND
FAU - Galegov, G A
AU  - Galegov GA
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Antibiot Khimioter
JT  - Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]
JID - 8803688
RN  - 0 (Antiviral Agents)
RN  - 364P9RVW4X (Foscarnet)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/*pharmacology
MH  - Antiviral Agents/*pharmacology
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Cytopathogenic Effect, Viral
MH  - Dose-Response Relationship, Drug
MH  - Foscarnet/*pharmacology
MH  - Herpesvirus 6, Human/*drug effects/physiology
MH  - Humans
MH  - Virus Replication/*drug effects
EDAT- 2009/06/09 09:00
MHDA- 2009/07/18 09:00
CRDT- 2009/06/09 09:00
PHST- 2009/06/09 09:00 [entrez]
PHST- 2009/06/09 09:00 [pubmed]
PHST- 2009/07/18 09:00 [medline]
PST - ppublish
SO  - Antibiot Khimioter. 2009;54(1-2):17-9.