PMID- 19500776
OWN - NLM
STAT- MEDLINE
DCOM- 20091021
LR  - 20161125
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 66
IP  - 5
DP  - 2009 Sep 1
TI  - Genetic variation in brain-derived neurotrophic factor is associated with 
      serotonin transporter but not serotonin-1A receptor availability in men.
PG  - 477-85
LID - 10.1016/j.biopsych.2009.04.009 [doi]
AB  - BACKGROUND: The serotonergic system, including the serotonin transporter (5-HTT), 
      which is the target of many antidepressants, seems to be influenced by 
      brain-derived neurotrophic factor (BDNF). METHODS: Positron emission tomography 
      (PET) was used to address, in 25 and 53 healthy volunteers, respectively, the 
      possible association between six polymorphisms in the gene encoding BDNF and the 
      availability of two proteins expressed by serotonergic neurons: the 5-HTT, 
      measured with the radioligand [(11)C]MADAM, and the serotonin-1A (5-HT1A) 
      receptor, measured with [(11)C]WAY-100635. RESULTS: Several single nucleotide 
      polymorphisms were associated with [(11)C]MADAM binding potential (BP) in most 
      brain regions, male carriers of the valine/valine genotype of the Val66Met 
      polymorphism displaying higher availability. Effect sizes ranged from a 50% to a 
      threefold increase. In contrast, there was no association for [(11)C]WAY-100635 
      BP. The observation that BDNF polymorphisms were associated with 5-HTT 
      availability could be partly replicated in an independent population comprising 
      nine male suicide attempters and nine matched control subjects, in which 
      transporter availability had been measured with single photon emission computed 
      tomography with (123)I-beta-CIT as ligand. CONCLUSIONS: Our results suggest that 
      genetic variation in BDNF influences 5-HTT but not 5-HT1A receptor density in the 
      human brain.
FAU - Henningsson, Susanne
AU  - Henningsson S
AD  - Institute of Neuroscience and Physiology, Department of Pharmacology, Gothenburg 
      University, Gothenburg, Sweden. susanne.henningsson@pharm.gu.se
FAU - Borg, Jacqueline
AU  - Borg J
FAU - Lundberg, Johan
AU  - Lundberg J
FAU - Bah, Jessica
AU  - Bah J
FAU - Lindstrom, Mats
AU  - Lindstrom M
FAU - Ryding, Erik
AU  - Ryding E
FAU - Jovanovic, Hristina
AU  - Jovanovic H
FAU - Saijo, Tomoyuki
AU  - Saijo T
FAU - Inoue, Makoto
AU  - Inoue M
FAU - Rosen, Ingmar
AU  - Rosen I
FAU - Traskman-Bendz, Lil
AU  - Traskman-Bendz L
FAU - Farde, Lars
AU  - Farde L
FAU - Eriksson, Elias
AU  - Eriksson E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090605
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/diagnostic imaging/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Radioligand Assay/methods
MH  - Radionuclide Imaging
MH  - Receptor, Serotonin, 5-HT1A/*metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/*metabolism
MH  - Sex Characteristics
MH  - Suicide, Attempted
EDAT- 2009/06/09 09:00
MHDA- 2009/10/22 06:00
CRDT- 2009/06/09 09:00
PHST- 2008/12/07 00:00 [received]
PHST- 2009/03/23 00:00 [revised]
PHST- 2009/04/02 00:00 [accepted]
PHST- 2009/06/09 09:00 [entrez]
PHST- 2009/06/09 09:00 [pubmed]
PHST- 2009/10/22 06:00 [medline]
AID - S0006-3223(09)00451-X [pii]
AID - 10.1016/j.biopsych.2009.04.009 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2009 Sep 1;66(5):477-85. doi: 10.1016/j.biopsych.2009.04.009. 
      Epub 2009 Jun 5.