PMID- 19501206
OWN - NLM
STAT- MEDLINE
DCOM- 20090811
LR  - 20101118
IS  - 1873-2941 (Electronic)
IS  - 0009-3084 (Linking)
VI  - 160
IP  - 1
DP  - 2009 Jul
TI  - Membrane permeabilization by Islet Amyloid Polypeptide.
PG  - 1-10
LID - 10.1016/j.chemphyslip.2009.03.008 [doi]
AB  - Membrane permeabilization by Islet Amyloid Polypeptide (IAPP) is suggested to be 
      the main mechanism for IAPP-induced cytotoxicity and death of insulin-producing 
      beta-cells in type 2 diabetes mellitus (T2DM). The insoluble fibrillar IAPP 
      deposits (amyloid) present in the pancreas of most T2DM patients are not the 
      primary suspects responsible for permeabilization of beta-cell membranes. 
      Instead, soluble IAPP oligomers are thought to be cytotoxic by forming membrane 
      channels or by inducing bilayer disorder. In addition, the elongation of IAPP 
      fibrils at the membrane, but not the fibrils themselves, could cause membrane 
      disruption. Recent reports substantiate the formation of an alpha-helical, 
      membrane-bound IAPP monomer as possible intermediate on the aggregation pathway. 
      Here, the structures and membrane interactions of various IAPP species will be 
      reviewed, and the proposed hypotheses for IAPP-induced membrane permeabilization 
      and cytotoxicity will be discussed.
FAU - Engel, Maarten F M
AU  - Engel MF
AD  - Astbury Centre for Structural Molecular Biology and Institute of Molecular and 
      Cellular Biology, University of Leeds, UK. m.engel@leeds.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090407
PL  - Ireland
TA  - Chem Phys Lipids
JT  - Chemistry and physics of lipids
JID - 0067206
RN  - 0 (Amyloid)
RN  - 0 (Islet Amyloid Polypeptide)
RN  - 0 (Lipid Bilayers)
SB  - IM
MH  - Amino Acid Sequence
MH  - Amyloid/*chemistry/metabolism/toxicity/ultrastructure
MH  - Cell Membrane Permeability/*physiology
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Humans
MH  - Insulin-Secreting Cells/metabolism
MH  - Islet Amyloid Polypeptide
MH  - Lipid Bilayers/metabolism
MH  - Molecular Sequence Data
RF  - 117
EDAT- 2009/06/09 09:00
MHDA- 2009/08/12 09:00
CRDT- 2009/06/09 09:00
PHST- 2009/02/14 00:00 [received]
PHST- 2009/03/26 00:00 [revised]
PHST- 2009/03/27 00:00 [accepted]
PHST- 2009/06/09 09:00 [entrez]
PHST- 2009/06/09 09:00 [pubmed]
PHST- 2009/08/12 09:00 [medline]
AID - S0009-3084(09)00074-7 [pii]
AID - 10.1016/j.chemphyslip.2009.03.008 [doi]
PST - ppublish
SO  - Chem Phys Lipids. 2009 Jul;160(1):1-10. doi: 10.1016/j.chemphyslip.2009.03.008. 
      Epub 2009 Apr 7.