PMID- 19501982
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20100917
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 35
IP  - 7
DP  - 2009 Nov
TI  - Antibiotic resistance in clinical isolates of Acinetobacter baumannii, 
      Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to 
      human beta defensin 4.
PG  - 949-55
LID - 10.1016/j.burns.2009.02.016 [doi]
AB  - Antibiotic usage is essential for infection control but hastens emergence of 
      antibiotic resistant microbes. In particular, Acinetobacter baumannii is an 
      important pathogen because of its heightened ability to acquire drug resistance. 
      The need for novel antibacterial agents led us to evaluate the sensitivity of 
      drug-resistant bacteria to the antimicrobial activity of human beta defensin 4 
      (HBD-4). Clinical isolates of A. baumannii (N=14), Pseudomonas aeruginosa (N=15), 
      and Staphylococcus aureus (N=20), including 10 methicillin-resistant (MRSA) 
      isolates, were examined. All bacterial strains were susceptible to HBD-4 
      antimicrobial activity, with no correlation between antibiotic resistance and 
      HBD-4 sensitivity. The results demonstrate that antibiotic resistant 
      microorganisms, including MRSA, can be inhibited by HBD-4, which may represent an 
      effective therapeutic agent for infections involving drug-resistant 
      microorganisms.
FAU - Supp, Dorothy M
AU  - Supp DM
AD  - Shriners Hospitals for Children, Cincinnati Burns Hospital, Cincinnati, OH 45229, 
      USA. dsupp@shrinenet.org
FAU - Gardner, Jason
AU  - Gardner J
FAU - Klingenberg, Jennifer M
AU  - Klingenberg JM
FAU - Neely, Alice N
AU  - Neely AN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090606
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (DEFB4A protein, human)
RN  - 0 (beta-Defensins)
SB  - IM
MH  - Acinetobacter baumannii/*drug effects/isolation & purification
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Burns/*microbiology
MH  - Drug Evaluation
MH  - Drug Resistance, Multiple, Bacterial
MH  - Humans
MH  - Methicillin Resistance
MH  - Microbial Sensitivity Tests/methods
MH  - Pseudomonas aeruginosa/*drug effects/isolation & purification
MH  - Staphylococcus aureus/*drug effects/isolation & purification
MH  - Wound Infection/microbiology
MH  - beta-Defensins/*pharmacology
EDAT- 2009/06/09 09:00
MHDA- 2010/07/22 06:00
CRDT- 2009/06/09 09:00
PHST- 2009/01/16 00:00 [received]
PHST- 2009/02/23 00:00 [revised]
PHST- 2009/02/24 00:00 [accepted]
PHST- 2009/06/09 09:00 [entrez]
PHST- 2009/06/09 09:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
AID - S0305-4179(09)00085-0 [pii]
AID - 10.1016/j.burns.2009.02.016 [doi]
PST - ppublish
SO  - Burns. 2009 Nov;35(7):949-55. doi: 10.1016/j.burns.2009.02.016. Epub 2009 Jun 6.