PMID- 19502265
OWN - NLM
STAT- MEDLINE
DCOM- 20090910
LR  - 20220408
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 18
IP  - 8
DP  - 2009 Jul
TI  - Molecular analysis of HLA-DRB1 allelic associations with systemic lupus 
      erythematous and lupus nephritis in Taiwan.
PG  - 698-704
LID - 10.1177/0961203308101955 [doi]
AB  - To evaluate the association of human leukocyte antigen (HLA)-DRB1 alleles with 
      systemic lupus erythematosus (SLE) and lupus nephritis (LN) in the Taiwanese 
      population, and to investigate the possible association of HLA-DRB1 alleles with 
      disease severity in LN. HLA-DRB1 alleles were studied in 105 SLE patients (82 
      patients with LN, 23 patients without LN) and 855 healthy controls by polymerase 
      chain reaction and sequence-based typing assays. The frequency of the HLA class 
      II alleles DRB1*0301 (Odds ratio [OR] = 2.01, 95% confidence interval [CI] = 
      1.31-3.10, Pc = 0.02) and DRB1*1501 (OR = 2.06, 95% CI = 1.36-3.13, Pc = 0.01) 
      were both increased in SLE patients, compared to healthy controls. The frequency 
      of DRB1*1202 was significantly lower in LN patients than in SLE patients without 
      nephritis (OR = 0.23, 95% CI = 0.09-0.57, Pc = 0.01). No specific allele was 
      significantly associated with an increased or decreased risk for severity of LN 
      in this sample. In Taiwanese people, the DRB1*0301 and DRB1*1501 alleles are 
      significant risk factors for SLE, while the DRB1*1202 allele is protective for 
      LN.
FAU - Pan, C F
AU  - Pan CF
AD  - Departments of Nephrology, Mackay Memorial Hospital, Taipei; Departments of 
      Mackay Medicine, Nursing and Management College, Taipei, Taiwan.
FAU - Wu, C J
AU  - Wu CJ
FAU - Chen, H H
AU  - Chen HH
FAU - Dang, C W
AU  - Dang CW
FAU - Chang, F M
AU  - Chang FM
FAU - Liu, H F
AU  - Liu HF
FAU - Chu, C C
AU  - Chu CC
FAU - Lin, M
AU  - Lin M
FAU - Lee, Y J
AU  - Lee YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (HLA-DRB1*12:02 antigen)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics/immunology/physiopathology
MH  - Lupus Nephritis/*genetics/immunology
MH  - Male
MH  - Taiwan
EDAT- 2009/06/09 09:00
MHDA- 2009/09/11 06:00
CRDT- 2009/06/09 09:00
PHST- 2009/06/09 09:00 [entrez]
PHST- 2009/06/09 09:00 [pubmed]
PHST- 2009/09/11 06:00 [medline]
AID - 18/8/698 [pii]
AID - 10.1177/0961203308101955 [doi]
PST - ppublish
SO  - Lupus. 2009 Jul;18(8):698-704. doi: 10.1177/0961203308101955.