PMID- 19502967
OWN - NLM
STAT- MEDLINE
DCOM- 20090708
LR  - 20211203
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 87
IP  - 11
DP  - 2009 Jun 15
TI  - Renal after cardiothoracic transplant: the effect of repeat mismatches on 
      outcome.
PG  - 1727-32
LID - 10.1097/TP.0b013e3181a60c51 [doi]
AB  - BACKGROUND: Histocompatibility matching is not considered important in nonrenal 
      solid organ transplants (NRSOT). There is no evidence to base guidance on whether 
      mismatched human leukocyte antigen (HLA) antigens should be avoided in subsequent 
      renal transplantation. METHODS: This study examines the effect of repeat HLA 
      mismatches on renal allograft survival and function in all renal after 
      cardiothoracic transplants undertaken in the United Kingdom between 1997 and 2003 
      using the UK Transplant data. RESULTS: A repeat HLA-A, -B, or -DR mismatch 
      occurred in 16 of 53 (30%) cases. Recipients without a repeat mismatch were more 
      likely to be male, but recipient age, donor age, recipient-donor age difference, 
      donor gender, donor type, or cold ischemia time were comparable. 
      Immunosuppressive therapy was similar in both groups. No differences were 
      observed in renal allograft function at 1 or 5 years between the repeat mismatch 
      group (estimated glomerular filtration rate [mean+/-standard deviation] 
      41.6+/-16.6 and 37.5+/-12.8 mL/min/1.73 m2) and the no repeat mismatch group 
      (47.2+/-15.7 and 48.0+/-15.9 mL/min/1.73 m2). Renal allograft survival was also 
      similar in the two groups at 1 and 5 years. CONCLUSIONS: In this limited, 
      heterogeneous, observational cohort of cardiothoracic transplant patients who 
      went on to receive a sequential kidney transplant, a repeated HLA antigen 
      mismatch was not associated with a detrimental effect on kidney transplant 
      outcome.
FAU - Caskey, Fergus J
AU  - Caskey FJ
AD  - Richard Bright Renal Unit, Southmead Hospital, Bristol, United Kingdom. 
      fjcaskey@doctors.org.uk
FAU - Johnson, Rachel J
AU  - Johnson RJ
FAU - Fuggle, Susan V
AU  - Fuggle SV
FAU - Start, Samantha
AU  - Start S
FAU - Pugh, Diana
AU  - Pugh D
FAU - Dudley, Christopher R K
AU  - Dudley CR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Graft Survival/immunology
MH  - HLA Antigens/*immunology
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Heart Transplantation/*immunology/statistics & numerical data
MH  - Heart-Lung Transplantation/*immunology/statistics & numerical data
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunosuppression Therapy/*methods
MH  - Kidney Transplantation/*immunology/mortality/statistics & numerical data
MH  - Lung Transplantation/*immunology/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - Tissue Donors/statistics & numerical data
EDAT- 2009/06/09 09:00
MHDA- 2009/07/09 09:00
CRDT- 2009/06/09 09:00
PHST- 2009/06/09 09:00 [entrez]
PHST- 2009/06/09 09:00 [pubmed]
PHST- 2009/07/09 09:00 [medline]
AID - 00007890-200906150-00019 [pii]
AID - 10.1097/TP.0b013e3181a60c51 [doi]
PST - ppublish
SO  - Transplantation. 2009 Jun 15;87(11):1727-32. doi: 10.1097/TP.0b013e3181a60c51.