PMID- 19505571
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20131121
IS  - 1873-6300 (Electronic)
IS  - 0891-0618 (Linking)
VI  - 38
IP  - 4
DP  - 2009 Dec
TI  - Morphological reorganization after repeated corticosterone administration in the 
      hippocampus, nucleus accumbens and amygdala in the rat.
PG  - 266-72
LID - 10.1016/j.jchemneu.2009.05.009 [doi]
AB  - Elevated levels of corticosteroids and stress play key roles in the 
      pathophysiology of affective disorders. Corticosterone (CORT)-treated rats have 
      emerged as a pharmacological model of depression-like behaviors. Previous studies 
      have shown that CORT administration induces neuronal atrophy in the CA3 subfield 
      of the hippocampus and laminae II/III of the prefrontal cortex. However, little 
      attention has been given to other limbic structures such as the amygdala and the 
      nucleus accumbens (NAcc). We investigated here whether 3 weeks of CORT 
      administration in rats causes dendritic remodeling and spine density 
      reorganization in the basolateral amygdala and pyramidal neurons of the CA1 
      subfield of the hippocampus as well as in spiny medium neurons of NAcc. 
      Quantitative morphological analysis revealed retracted neuronal arborizations and 
      modified configuration of length depending on branch order in medium spiny 
      neurons of the NAcc of CORT-treated animals. Moreover, distal dendritic sections 
      of the NAcc showed massive reductions in the number of spines caused by the CORT 
      treatment. This treatment also induced a reduction in total dendritic length 
      specific to fourth and sixth branch orders of pyramidal CA1 hippocampal neurons. 
      These neurons also showed decreased branching and diminished number of spines. 
      Finally, pyramidal neurons of the basolateral amygdala were apparently not 
      significantly affected by the CORT treatment. Taken together, these data show for 
      the first time neuronal morphological alterations in the NAcc in the CORT model 
      of depression-like behaviors. Our results also add further information about the 
      morphological reorganization occurring in CORT-sensitive regions of the limbic 
      system.
FAU - Morales-Medina, Julio Cesar
AU  - Morales-Medina JC
AD  - Dept of Neurology & Neurosurgery, McGill University, Montreal, QC, Canada.
FAU - Sanchez, Fremioht
AU  - Sanchez F
FAU - Flores, Gonzalo
AU  - Flores G
FAU - Dumont, Yvan
AU  - Dumont Y
FAU - Quirion, Remi
AU  - Quirion R
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090606
PL  - Netherlands
TA  - J Chem Neuroanat
JT  - Journal of chemical neuroanatomy
JID - 8902615
RN  - 0 (Anti-Inflammatory Agents)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Amygdala/drug effects/metabolism/pathology
MH  - Animals
MH  - Anti-Inflammatory Agents/metabolism/toxicity
MH  - Cell Shape/drug effects/physiology
MH  - Corticosterone/metabolism/*toxicity
MH  - Dendrites/drug effects/metabolism/pathology
MH  - Dendritic Spines/drug effects/metabolism/pathology
MH  - Disease Models, Animal
MH  - Drug Administration Schedule
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Limbic System/drug effects/metabolism/*pathology
MH  - Male
MH  - Neural Pathways/drug effects/metabolism/pathology
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Neurons/drug effects/metabolism/*pathology
MH  - Nucleus Accumbens/drug effects/metabolism/pathology
MH  - Pyramidal Cells/drug effects/metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Silver Staining
MH  - Stress, Psychological/metabolism/*pathology/physiopathology
EDAT- 2009/06/10 09:00
MHDA- 2010/01/27 06:00
CRDT- 2009/06/10 09:00
PHST- 2009/03/08 00:00 [received]
PHST- 2009/05/17 00:00 [revised]
PHST- 2009/05/27 00:00 [accepted]
PHST- 2009/06/10 09:00 [entrez]
PHST- 2009/06/10 09:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - S0891-0618(09)00076-3 [pii]
AID - 10.1016/j.jchemneu.2009.05.009 [doi]
PST - ppublish
SO  - J Chem Neuroanat. 2009 Dec;38(4):266-72. doi: 10.1016/j.jchemneu.2009.05.009. 
      Epub 2009 Jun 6.