PMID- 19505720 OWN - NLM STAT- MEDLINE DCOM- 20100310 LR - 20211020 IS - 1873-5835 (Electronic) IS - 0145-2126 (Print) IS - 0145-2126 (Linking) VI - 34 IP - 2 DP - 2010 Feb TI - Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study. PG - 190-5 LID - 10.1016/j.leukres.2009.05.007 [doi] AB - We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes. CI - Copyright 2009 Elsevier Ltd. All rights reserved. FAU - Chang, Cindy M AU - Chang CM AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., EPS 7074, Rockville, MD 20892, USA. changcm@mail.nih.gov FAU - Schroeder, Jane C AU - Schroeder JC FAU - Huang, Wen-Yi AU - Huang WY FAU - Dunphy, Cherie H AU - Dunphy CH FAU - Baric, Ralph S AU - Baric RS FAU - Olshan, Andrew F AU - Olshan AF FAU - Dorsey, Kathleen C AU - Dorsey KC FAU - Dent, Georgette A AU - Dent GA FAU - Cerhan, James R AU - Cerhan JR FAU - Lynch, Charles F AU - Lynch CF FAU - Rothman, Nathaniel AU - Rothman N FAU - Cantor, Kenneth P AU - Cantor KP FAU - Blair, Aaron AU - Blair A LA - eng GR - P30 ES010126/ES/NIEHS NIH HHS/United States GR - R24 HD050924/HD/NICHD NIH HHS/United States GR - P30ES10126/ES/NIEHS NIH HHS/United States GR - R21 CA107966-01/CA/NCI NIH HHS/United States GR - R03 CA71617-01/CA/NCI NIH HHS/United States PT - Evaluation Study PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20090607 PL - England TA - Leuk Res JT - Leukemia research JID - 7706787 RN - 0 (Proto-Oncogene Proteins c-bcl-2) SB - IM MH - Case-Control Studies MH - Chromosomes, Human, Pair 14 MH - Chromosomes, Human, Pair 18 MH - Humans MH - In Situ Hybridization, Fluorescence/*methods/standards MH - Lymphoma, Follicular/*genetics MH - Lymphoma, Large B-Cell, Diffuse/*genetics MH - Lymphoma, Non-Hodgkin/*classification/*genetics MH - Proto-Oncogene Proteins c-bcl-2/analysis MH - *Translocation, Genetic PMC - PMC2815151 MID - NIHMS157999 EDAT- 2009/06/10 09:00 MHDA- 2010/03/11 06:00 PMCR- 2010/02/02 CRDT- 2009/06/10 09:00 PHST- 2009/03/26 00:00 [received] PHST- 2009/05/07 00:00 [revised] PHST- 2009/05/12 00:00 [accepted] PHST- 2009/06/10 09:00 [entrez] PHST- 2009/06/10 09:00 [pubmed] PHST- 2010/03/11 06:00 [medline] PHST- 2010/02/02 00:00 [pmc-release] AID - S0145-2126(09)00260-4 [pii] AID - 10.1016/j.leukres.2009.05.007 [doi] PST - ppublish SO - Leuk Res. 2010 Feb;34(2):190-5. doi: 10.1016/j.leukres.2009.05.007. Epub 2009 Jun 7.